{"id":"W2003352123","doi":"10.1016/j.molimm.2009.04.024","title":"Thermodynamic characterization of the interactions between the immunoregulatory proteins osteopontin and lactoferrin","year":2009,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Infant Nutrition and Health","field":"Nursing","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Isothermal titration calorimetry; Lactoferrin; Osteopontin; Chemistry; Cooperative binding; Dissociation constant; Biochemistry; Molecular binding; Plasma protein binding; Biophysics; Circular dichroism; Molecule; Binding site; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001344745,0.0001004873,0.0001550046,0.00006553959,0.000217423,0.00001623865,0.0001912583,0.00008572825,0.00002235672],"category_scores_gemma":[0.00002495814,0.00006644357,0.00006637353,0.0001410689,0.0001560698,0.00006071099,0.00004156976,0.0002733999,0.000005060097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004151259,"about_ca_system_score_gemma":0.00001918587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000450167,"about_ca_topic_score_gemma":0.00000936715,"domain_scores_codex":[0.9990715,0.0002942522,0.0002447016,0.0001311526,0.00008412472,0.0001742121],"domain_scores_gemma":[0.9993669,0.00002912485,0.0001724655,0.000364662,0.00005271635,0.00001415597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007091594,0.00003560555,0.0008048275,0.000007815308,0.0000229197,5.500647e-7,0.000485307,2.565179e-7,0.9835482,0.00187625,0.000007544568,0.01313981],"study_design_scores_gemma":[0.0004273033,0.0001523896,0.8485975,0.00004821371,0.0000297208,0.00002214516,0.00006423334,0.00006072602,0.146218,0.001023368,0.003274777,0.00008165577],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859675,0.0002622209,0.0002917928,0.01226361,0.0002691276,0.0005031879,0.00001137591,0.00003084213,0.0004003341],"genre_scores_gemma":[0.9988459,0.0000168809,0.00003534135,0.0009630094,0.00003094272,0.00001424963,0.00002666964,0.00001134045,0.00005562988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8477927,"threshold_uncertainty_score":0.270949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006501357927085522,"score_gpt":0.2442632834521103,"score_spread":0.2377619255250247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}