{"id":"W2003362321","doi":"10.1038/nature02451","title":"Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms","year":2004,"lang":"en","type":"article","venue":"Nature","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":418,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Merck Canada Inc. (Canada)","funders":"National Institute of General Medical Sciences; RIKEN; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Caspase; Biology; Apoptosis; Cytokine; Endoplasmic reticulum; Lipopolysaccharide; Cell biology; Single-nucleotide polymorphism; Immunology; Programmed cell death; Gene; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000343345,0.0003815977,0.0003693071,0.0005333033,0.0001069589,0.0002613909,0.0002223413,0.0004196093,0.003017619],"category_scores_gemma":[0.001043323,0.0002258068,0.0003015527,0.000278302,0.0002666665,0.0001871316,0.0002847557,0.0005512974,0.0003377398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001152308,"about_ca_system_score_gemma":0.00007107333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002486818,"about_ca_topic_score_gemma":0.000151562,"domain_scores_codex":[0.9994516,0.000233107,0.00005870761,0.0001337225,0.0000550105,0.00006784382],"domain_scores_gemma":[0.9990813,0.0003621334,0.000229294,0.0001345244,0.00005475896,0.0001380012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.009910998,0.0002526123,0.05999301,0.00003675823,0.0001750868,0.0006689154,0.0001801638,0.0002611763,0.9222741,0.0003089268,0.0001254961,0.005812636],"study_design_scores_gemma":[0.0003709357,0.003217548,0.857469,0.00002131347,0.0002653505,0.004495543,0.0001784792,0.002492339,0.1297931,0.0005775638,0.001073792,0.00004499708],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989479,0.0001246963,0.0005493013,0.00003499377,0.000009788405,0.000005976289,0.0001257312,0.000009420556,0.0001921858],"genre_scores_gemma":[0.9991666,0.000047498,0.0002140147,0.00002915165,0.000007368174,0.000008072154,0.0001319511,0.00001343791,0.0003819179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003017619,"threshold_uncertainty_score":0.010095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004567272838475438,"score_gpt":0.2466150826363264,"score_spread":0.2420478097978509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}