{"id":"W2003415831","doi":"10.1016/j.canlet.2015.04.003","title":"Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673","year":2015,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; McGill University Health Centre; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; McGill University","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Institut de recherche, Centre universitaire de santé McGill","keywords":"Cisplatin; Veliparib; Poly ADP ribose polymerase; Cancer research; PARP inhibitor; Gene knockdown; Biology; In vivo; Pancreatic cancer; Apoptosis; DNA damage; Molecular biology; Cancer; Polymerase; Chemotherapy; DNA; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003512202,0.0003232685,0.0003916359,0.0003206512,0.0001868775,0.0004414208,0.000222877,0.0003863226,0.004032704],"category_scores_gemma":[0.0003762611,0.0002504199,0.0002919112,0.0002114515,0.0002145929,0.0002020005,0.0001374772,0.001204504,0.000705767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004024066,"about_ca_system_score_gemma":0.0002214297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009817133,"about_ca_topic_score_gemma":0.0007765276,"domain_scores_codex":[0.9997403,0.00009381538,0.00001933676,0.00003930819,0.00005209108,0.00005512072],"domain_scores_gemma":[0.9997345,0.0001163669,0.00002910791,0.00004351729,0.00002177397,0.00005470234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007548142,0.0001655794,0.0003008892,0.00003378272,0.00001543924,0.00005256157,0.00001631101,0.0001462262,0.9963825,0.00005453953,0.0002414127,0.001835977],"study_design_scores_gemma":[0.00004380607,0.001152439,0.004307133,0.000004674889,0.00001979919,0.000326904,0.00002096659,0.001029747,0.9918044,0.00002997288,0.001256276,0.000003912682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908091,0.003698876,0.001984058,0.0002294679,0.0000986231,0.00002388282,0.0007393637,0.0001325108,0.002284135],"genre_scores_gemma":[0.9932684,0.001060177,0.001070475,0.0001041262,0.0000334908,0.00002914152,0.001491045,0.00004420908,0.002898806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004032704,"threshold_uncertainty_score":0.01349074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0291063017790881,"score_gpt":0.3225897937684973,"score_spread":0.2934834919894092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}