{"id":"W2003446114","doi":"10.1016/j.ijpddr.2014.07.007","title":"Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions","year":2014,"lang":"en","type":"review","venue":"International Journal for Parasitology Drugs and Drug Resistance","topic":"Helminth infection and control","field":"Veterinary","cited_by":214,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Biotechnology and Biological Sciences Research Council; Zoetis","keywords":"Anthelmintic; Drug resistance; Biology; Resistance (ecology); Computational biology; Drug discovery; Biotechnology; Bioinformatics; Genetics; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001374784,0.0002994806,0.00104571,0.0002964221,0.0002090268,0.000130478,0.0003895951,0.00009094155,0.000009932735],"category_scores_gemma":[0.0003024638,0.0001816142,0.0002155798,0.0001544152,0.0004667665,0.0003052097,0.00009661823,0.0003981328,0.000001852158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001190289,"about_ca_system_score_gemma":0.0001006768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002660123,"about_ca_topic_score_gemma":0.001414336,"domain_scores_codex":[0.9974433,0.0006462852,0.001063186,0.000372156,0.0002457359,0.0002293801],"domain_scores_gemma":[0.9972489,0.001276949,0.0009927854,0.0002191912,0.0001846023,0.00007749896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.021389,0.0003665988,0.001086442,0.007707686,0.002166609,0.00003652758,0.006754692,0.00004216497,0.0001625986,0.02026174,0.005376817,0.9346491],"study_design_scores_gemma":[0.001187004,0.00004383294,0.0002920802,0.002455182,0.0001973083,0.0001831952,0.0006428019,0.0000268067,0.000005622195,0.0007814667,0.9939965,0.0001881763],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006911865,0.9839892,0.001204679,0.004697738,0.001413492,0.0009184272,0.0004255778,0.000006490036,0.000432511],"genre_scores_gemma":[0.06678326,0.9303839,0.0002229221,0.00009502881,0.0002314091,0.000223328,0.00004199509,0.00002505691,0.001993166],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9886197,"threshold_uncertainty_score":0.7406012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05256629548154994,"score_gpt":0.3547633936037349,"score_spread":0.3021970981221849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}