{"id":"W2003446426","doi":"10.1074/jbc.m704459200","title":"A Novel Interaction between Procaspase 8 and SPARC Enhances Apoptosis and Potentiates Chemotherapy Sensitivity in Colorectal Cancers","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Apoptosis; Chemotherapy; Sensitivity (control systems); Cancer research; Medicine; Colorectal cancer; Oncology; Internal medicine; Chemistry; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001328543,0.0002245602,0.0002290902,0.0001363354,0.0001127899,0.0001711963,0.0001235387,0.0001890449,0.000620485],"category_scores_gemma":[0.0001349798,0.0001090923,0.000170391,0.00007980882,0.0001413585,0.0001161513,0.0001780642,0.000341787,0.0001568746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002883974,"about_ca_system_score_gemma":0.0001063759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002466426,"about_ca_topic_score_gemma":0.0005571558,"domain_scores_codex":[0.9998832,0.0000278606,0.000007234898,0.00001876647,0.00004040293,0.0000224629],"domain_scores_gemma":[0.9999338,0.00001368176,0.00001835965,0.000006766576,0.000007854315,0.00001945406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009699793,0.00002843098,0.0003318539,0.00002254741,0.000008734201,0.0001562987,0.00000473707,0.00007863241,0.9977557,0.00007642728,0.00003324369,0.001406402],"study_design_scores_gemma":[0.00005936181,0.0008339894,0.01736398,0.000006299426,0.00004270895,0.002020936,0.00001763035,0.002225731,0.9735019,0.00008423862,0.003836792,0.000006395601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962783,0.001429495,0.001394761,0.0001252627,0.00001343378,0.00001062352,0.00003715587,0.00003003962,0.0006808845],"genre_scores_gemma":[0.9972171,0.0004954998,0.001216746,0.00007270651,0.00001028636,0.00000808435,0.00009080819,0.000004444678,0.0008842991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000620485,"threshold_uncertainty_score":0.002092481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440721861801926,"score_gpt":0.2687995448160258,"score_spread":0.2543923261980066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}