{"id":"W2003455873","doi":"10.4161/cc.24740","title":"Centromere fragmentation is a common mitotic defect of S and G<sub>2</sub>checkpoint override","year":2013,"lang":"en","type":"article","venue":"Cell Cycle","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; National Institutes of Health; National Institute of General Medical Sciences; U.S. Department of Defense","keywords":"Biology; Centromere; Mitosis; Spindle checkpoint; Kinetochore; Mitotic catastrophe; Mad2; Cell biology; Chromatin; Cell cycle checkpoint; Metaphase; G2-M DNA damage checkpoint; Chromosome segregation; Topoisomerase; Interphase; Cell cycle; Genetics; Chromosome; Apoptosis; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001799637,0.0004923447,0.0004294186,0.0004818455,0.0001394353,0.0002286344,0.0001518201,0.0003924153,0.001626312],"category_scores_gemma":[0.0001944283,0.0002054591,0.0002809,0.0003217554,0.0002098759,0.0001889511,0.0002686618,0.0003757207,0.0002823343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002256068,"about_ca_system_score_gemma":0.0001474252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005548677,"about_ca_topic_score_gemma":0.0009328257,"domain_scores_codex":[0.9998125,0.00002866757,0.00002646582,0.00004591194,0.00006242844,0.0000239721],"domain_scores_gemma":[0.9997289,0.00003908428,0.0001212113,0.00003809633,0.0000300104,0.00004276983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003125823,0.00002534701,0.003119629,0.0001047496,0.0000419891,0.0005570155,0.00003259385,0.0001171141,0.9909449,0.00008237076,0.000092881,0.004568854],"study_design_scores_gemma":[0.00003706053,0.001337404,0.1191664,0.00002570416,0.00005979987,0.008131525,0.00009891182,0.0006965847,0.8638375,0.0001561864,0.00643825,0.0000146142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983291,0.009722421,0.003950974,0.00009612442,0.00002194033,0.00006403633,0.0006828774,0.0001714404,0.001999248],"genre_scores_gemma":[0.9949473,0.00192842,0.0009089606,0.00006920486,0.000005351684,0.00002987458,0.000659538,0.00001513944,0.001436314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001626312,"threshold_uncertainty_score":0.005440533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004265685063949012,"score_gpt":0.2043692456858163,"score_spread":0.2001035606218673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}