{"id":"W2003461564","doi":"10.1007/s00726-011-1124-7","title":"Exploiting diverse stereochemistry of β-amino acids: toward a rational design of sheet-forming β-peptide systems","year":2011,"lang":"en","type":"article","venue":"Amino Acids","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Chirality (physics); Chemistry; Folding (DSP implementation); Foldamer; Enantiomer; Rational design; Stereochemistry; Amino acid; Side chain; Conformational isomerism; Molecule; Organic chemistry; Nanotechnology; Materials science; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005038955,0.0005178208,0.0003519054,0.00023453,0.0002385747,0.0004813488,0.0004422434,0.0002174522,0.0005118779],"category_scores_gemma":[0.0003617997,0.0002610736,0.0001731024,0.0002852839,0.0002698931,0.000488738,0.0002845901,0.0007011483,0.0002892742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000265358,"about_ca_system_score_gemma":0.0004830157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002617802,"about_ca_topic_score_gemma":0.0006493534,"domain_scores_codex":[0.9998947,0.00002970309,0.000010475,0.00001946639,0.00002467221,0.00002093823],"domain_scores_gemma":[0.9998695,0.00003157955,0.00003446925,0.00001455289,0.00002569219,0.00002420912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003417358,0.0001766817,0.0006470074,0.0002511302,0.00002495722,0.0003742753,0.000140568,0.02047133,0.937406,0.009552676,0.0002498481,0.03036383],"study_design_scores_gemma":[0.0001295602,0.001163494,0.0003991436,0.00003223572,0.00005425409,0.0003435334,0.00009160187,0.02432013,0.9622619,0.003544681,0.007620724,0.00003886242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9175557,0.001951735,0.0737121,0.0001785061,0.00005140711,0.0002260229,0.0001606231,0.0002146617,0.005949217],"genre_scores_gemma":[0.9551943,0.003026248,0.04049496,0.00012535,0.00001363003,0.00008179353,0.0001387219,0.00004371713,0.0008812715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005178208,"threshold_uncertainty_score":0.002664924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04566720456207268,"score_gpt":0.2380827019830128,"score_spread":0.1924154974209402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}