{"id":"W2003514819","doi":"10.1002/cbic.201000433","title":"A Chemical Method for Labeling Lysine Methyltransferase Substrates","year":2010,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; Life Sciences Research Foundation; Howard Hughes Medical Institute","keywords":"Methyltransferase; Histone; Chemical biology; Biochemistry; Lysine; DNA; Cofactor; Bioorthogonal chemistry; Chromatin; Alkyne; Click chemistry; Histone H3; Proteome; Chemistry; Enzyme; Biology; Combinatorial chemistry; Methylation; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006950075,0.0010988,0.0004009135,0.0008352068,0.0007183172,0.0003438795,0.000902181,0.001214316,0.004801167],"category_scores_gemma":[0.0005546998,0.0006564723,0.0005525892,0.0007071866,0.0004293718,0.0006715379,0.0004843581,0.002050172,0.003974915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005240366,"about_ca_system_score_gemma":0.0005244531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000391815,"about_ca_topic_score_gemma":0.001312102,"domain_scores_codex":[0.9993817,0.0001228674,0.00004533094,0.000161925,0.0002363242,0.00005184985],"domain_scores_gemma":[0.9995709,0.0001267241,0.00006977503,0.0001154322,0.00008010747,0.00003697223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003880754,0.00003354553,0.00005806444,0.0002609664,0.00001592494,0.00008696329,0.00002839342,0.000158762,0.9902033,0.001588268,0.0007409538,0.006785997],"study_design_scores_gemma":[0.00002604788,0.0002047088,0.000245783,0.00002364572,0.00002257203,0.0003388575,0.00001010013,0.0007186226,0.9647756,0.0003885228,0.03322654,0.00001909697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.07475933,0.008241874,0.8906809,0.00119806,0.0009117492,0.001249942,0.002001027,0.002192289,0.01876488],"genre_scores_gemma":[0.2728642,0.01512056,0.6685537,0.0009481264,0.0002177563,0.004288756,0.004136509,0.0005032034,0.03336722],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.004801167,"threshold_uncertainty_score":0.01606148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01050308675570919,"score_gpt":0.2984278076243764,"score_spread":0.2879247208686672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}