{"id":"W2003514819","doi":"10.1002/cbic.201000433","title":"A Chemical Method for Labeling Lysine Methyltransferase Substrates","year":2010,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; Life Sciences Research Foundation; Howard Hughes Medical Institute","keywords":"Methyltransferase; Histone; Chemical biology; Biochemistry; Lysine; DNA; Cofactor; Bioorthogonal chemistry; Chromatin; Alkyne; Click chemistry; Histone H3; Proteome; Chemistry; Enzyme; Biology; Combinatorial chemistry; Methylation; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003861621,0.0001823347,0.0001636775,0.00003034086,0.00006066084,0.00002714894,0.0001787811,0.0002754442,0.00003383994],"category_scores_gemma":[0.0002757294,0.0001624534,0.0001516695,0.00007839609,0.00005648436,0.000003010353,0.00003564831,0.0001119572,0.000005788747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005890946,"about_ca_system_score_gemma":0.0000538869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003370732,"about_ca_topic_score_gemma":0.00000984867,"domain_scores_codex":[0.9989465,0.00001737808,0.0002257936,0.0004303376,0.00009763846,0.0002823472],"domain_scores_gemma":[0.9992482,0.00006197302,0.00005322384,0.000348436,0.0001664102,0.0001217542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005464006,0.00004474068,0.0001652239,0.00002214921,0.00003696271,4.629194e-7,0.00001651012,0.000002050735,0.9913691,0.000323638,0.0001188619,0.007845717],"study_design_scores_gemma":[0.0007491065,0.00005435128,0.00003536644,0.000005454974,0.00003077576,0.000003531802,0.0000104131,0.0001006994,0.9846609,0.0009438909,0.01317073,0.0002347978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9229265,0.0005708145,0.07504401,0.0003424711,0.00018051,0.0002099084,0.00003887465,0.000023262,0.0006636648],"genre_scores_gemma":[0.9118914,0.00006329804,0.08666024,0.0001057987,0.0006076171,0.00006872575,0.0002324309,0.0000387546,0.0003317311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01305187,"threshold_uncertainty_score":0.6624656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01050308675570919,"score_gpt":0.2984278076243764,"score_spread":0.2879247208686672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}