{"id":"W2003514850","doi":"10.1210/me.2012-1370","title":"HIV-1 Vpr Enhances PPARβ/δ-Mediated Transcription, Increases PDK4 Expression, and Reduces PDC Activity","year":2013,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Children's National Hospital","keywords":"Biology; PDK4; Transcription (linguistics); Transcription factor; Cell biology; Human immunodeficiency virus (HIV); Peroxisome proliferator-activated receptor; Virology; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000140697,0.0004391709,0.0003218447,0.0005055869,0.0001919021,0.0003928909,0.0002327241,0.0002599325,0.001800159],"category_scores_gemma":[0.0001278257,0.0002091547,0.0003186305,0.0002374045,0.0003058078,0.0001804766,0.0002308302,0.0006900784,0.0004220442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005524181,"about_ca_system_score_gemma":0.0002233022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007839925,"about_ca_topic_score_gemma":0.0007279943,"domain_scores_codex":[0.9998172,0.00003283607,0.00001912458,0.00004084586,0.00004482183,0.0000452749],"domain_scores_gemma":[0.9999361,0.00001072455,0.00001593242,0.00001135773,0.000008705984,0.00001713468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001912347,0.00008517563,0.000248007,0.00005630044,0.000009814042,0.00003388553,0.00001154733,0.0001005655,0.9963276,0.00009798018,0.00009165512,0.002746229],"study_design_scores_gemma":[0.00004178696,0.0004280327,0.004914182,0.000009774722,0.00001860016,0.0002228027,0.00003251812,0.0006973951,0.9900879,0.00007958371,0.00346144,0.000005943229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897142,0.004253333,0.002151132,0.000224362,0.00007229448,0.00003872421,0.0008212912,0.0002091717,0.002515352],"genre_scores_gemma":[0.9889882,0.002007172,0.003150133,0.0001248023,0.0000199217,0.00005616553,0.001394873,0.00004679179,0.004211899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001800159,"threshold_uncertainty_score":0.006022096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006290720156822894,"score_gpt":0.2240821223602867,"score_spread":0.2177914022034639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}