{"id":"W2003514850","doi":"10.1210/me.2012-1370","title":"HIV-1 Vpr Enhances PPARβ/δ-Mediated Transcription, Increases PDK4 Expression, and Reduces PDC Activity","year":2013,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Children's National Hospital","keywords":"Biology; PDK4; Transcription (linguistics); Transcription factor; Cell biology; Human immunodeficiency virus (HIV); Peroxisome proliferator-activated receptor; Virology; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006531052,0.0003617575,0.0003309792,0.0001269348,0.0001502704,0.00005394857,0.0002870577,0.0002854619,0.0002408005],"category_scores_gemma":[0.0001939065,0.0003369194,0.0001003435,0.0001400073,0.0003485119,0.00002960664,0.0001734572,0.0002437184,0.0000989946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002124412,"about_ca_system_score_gemma":0.000077492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001413779,"about_ca_topic_score_gemma":0.000008287438,"domain_scores_codex":[0.9978502,0.0003057311,0.0002810447,0.0007516904,0.0001716163,0.0006397297],"domain_scores_gemma":[0.9990521,0.00003037307,0.0001262999,0.0004244305,0.0001428298,0.0002239884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001046059,0.0001466538,0.001346493,0.00001623791,0.0001104124,0.00001635584,0.00003917851,0.000005329169,0.9939673,0.00002671086,0.002473732,0.001746994],"study_design_scores_gemma":[0.0007793525,0.0002725178,0.00180555,0.0000147134,0.00002427025,0.0001029454,0.00008169994,0.00001601265,0.9869895,0.0001006676,0.009448286,0.0003644903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948192,0.002307741,0.001029424,0.0006443619,0.0001837111,0.000403175,0.00003708154,0.00008190751,0.0004933999],"genre_scores_gemma":[0.9971799,0.0008715516,0.0006114623,0.000429826,0.0001288434,0.0002772332,0.0001889373,0.00004901308,0.0002632805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006977802,"threshold_uncertainty_score":0.9999083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006290720156822894,"score_gpt":0.2240821223602867,"score_spread":0.2177914022034639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}