{"id":"W2003518997","doi":"10.1158/1535-7163.targ-09-a170","title":"Abstract A170: High-content screening for inhibitors of oncogenic transcription by c-Myc","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; McMaster University","funders":"","keywords":"Förster resonance energy transfer; Fluorescence; Bimolecular fluorescence complementation; Protein-fragment complementation assay; Protein–protein interaction; Computational biology; Transcription factor; Fluorescence microscope; Small molecule; Biology; Chemistry; Biochemistry; Cancer research; Cell biology; Gene; Complementation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001978938,0.0007121592,0.0003525542,0.0007194037,0.0002189242,0.0002511703,0.0003854899,0.0004683435,0.003752272],"category_scores_gemma":[0.0001596611,0.0001605798,0.0003079415,0.0004171159,0.0001214903,0.0001120441,0.0001789836,0.0004870143,0.000949422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002263351,"about_ca_system_score_gemma":0.0002386443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004457363,"about_ca_topic_score_gemma":0.0006658143,"domain_scores_codex":[0.9998259,0.00002298369,0.00001709377,0.00002121616,0.00008474768,0.0000281717],"domain_scores_gemma":[0.9998833,0.00002860858,0.00001488906,0.00001097631,0.00002664549,0.00003553726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001449215,0.0001201604,0.0001018524,0.0000470941,0.000009318049,0.00004518581,0.00000508257,0.0001029511,0.9962685,0.00005298867,0.000283278,0.002818686],"study_design_scores_gemma":[0.0000744811,0.001236229,0.001017406,0.000005581748,0.00002126356,0.0002444574,0.000005897109,0.0006713833,0.991828,0.00002900157,0.004859354,0.00000696233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9641404,0.004634368,0.01518277,0.0004505823,0.0001882083,0.0007534088,0.005192488,0.0007881148,0.008669632],"genre_scores_gemma":[0.9434086,0.003553448,0.02486196,0.0003599343,0.00007751123,0.0006854304,0.01233036,0.0002190401,0.0145038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003752272,"threshold_uncertainty_score":0.01255256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03336528089470042,"score_gpt":0.3012368638498766,"score_spread":0.2678715829551762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}