{"id":"W2003550137","doi":"10.1021/jm058179h","title":"Androsterone 3α-Ether-3β-Substituted and Androsterone 3β-Substituted Derivatives as Inhibitors of Type 3 17β-Hydroxysteroid Dehydrogenase:  Chemical Synthesis and Structure−Activity Relationship","year":2005,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Androsterone; Hydroxysteroid dehydrogenase; Stereochemistry; Ether; Dehydrogenase; Enzyme; Enzyme inhibitor; Chemical synthesis; Androgen; Steroid; Biochemistry; In vitro; Organic chemistry; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003458897,0.0002613483,0.0007183545,0.0001200444,0.00008155969,0.00001780675,0.00008552213,0.0002881429,0.0001442872],"category_scores_gemma":[0.001088949,0.0002038772,0.00007669187,0.0002312676,0.0004161847,0.0002323946,0.00004410303,0.0005282679,0.000001574716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001118621,"about_ca_system_score_gemma":0.0001817536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008069908,"about_ca_topic_score_gemma":0.000001512259,"domain_scores_codex":[0.9981635,0.000052998,0.0006676143,0.0002502085,0.0006521149,0.0002135573],"domain_scores_gemma":[0.9982348,0.0002961513,0.0005395828,0.000188709,0.0003172359,0.0004235147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00126947,0.0001370753,0.007566093,0.0002358916,0.0001405493,0.00008161706,0.0002683524,0.000006280868,0.9843794,0.000006868099,0.0002573025,0.005651147],"study_design_scores_gemma":[0.003058015,0.0002287972,0.01676842,0.0008467732,0.00039313,0.005063189,0.0001742033,0.0004339461,0.9718257,0.00005468574,0.0009596174,0.000193562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923241,0.005395761,0.00006248977,0.001821976,0.00005835577,0.0001319694,0.00001530538,0.00001424295,0.0001758365],"genre_scores_gemma":[0.9984351,0.0002339573,0.000744757,0.000106788,0.0003416687,0.000001386924,0.00001575996,0.00002398741,0.00009656104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01255369,"threshold_uncertainty_score":0.8313872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01735630016767898,"score_gpt":0.2654292308759719,"score_spread":0.2480729307082929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}