{"id":"W2003550137","doi":"10.1021/jm058179h","title":"Androsterone 3α-Ether-3β-Substituted and Androsterone 3β-Substituted Derivatives as Inhibitors of Type 3 17β-Hydroxysteroid Dehydrogenase:  Chemical Synthesis and Structure−Activity Relationship","year":2005,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Androsterone; Hydroxysteroid dehydrogenase; Stereochemistry; Ether; Dehydrogenase; Enzyme; Enzyme inhibitor; Chemical synthesis; Androgen; Steroid; Biochemistry; In vitro; Organic chemistry; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002046877,0.0006721805,0.0004946638,0.0002685379,0.0001143644,0.0002224142,0.0003272706,0.0002770427,0.001258598],"category_scores_gemma":[0.000129637,0.0002204695,0.0003727753,0.0004560048,0.0001789077,0.0002552859,0.0001676435,0.0005644923,0.0006621577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002452261,"about_ca_system_score_gemma":0.000299415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006195684,"about_ca_topic_score_gemma":0.001545327,"domain_scores_codex":[0.9998945,0.00002234743,0.000009399675,0.00001514988,0.00002730398,0.00003131253],"domain_scores_gemma":[0.9999256,0.000009915948,0.00001933929,0.000007774941,0.00001569556,0.00002162606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007754567,0.0003073779,0.000406941,0.0004762586,0.00005136928,0.0003867428,0.00008728939,0.001228166,0.9688455,0.0006667307,0.0002994377,0.02646872],"study_design_scores_gemma":[0.0002871711,0.004643688,0.003641132,0.00004113334,0.0001432892,0.001163839,0.00004176878,0.001083136,0.9587131,0.0001725802,0.03001753,0.0000516318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.874642,0.1003897,0.01282689,0.0002537578,0.0002495299,0.0004115824,0.001427483,0.0002180926,0.009581102],"genre_scores_gemma":[0.9253729,0.05681036,0.009506442,0.0002017847,0.00009313311,0.0001555748,0.001419549,0.00004660834,0.006393776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001258598,"threshold_uncertainty_score":0.004210472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01735630016767898,"score_gpt":0.2654292308759719,"score_spread":0.2480729307082929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}