{"id":"W2003551726","doi":"10.1021/bi0477135","title":"Combined N- and C-Terminal Truncation of Human Apolipoprotein A-I Yields a Folded, Functional Central Domain","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute","keywords":"Circular dichroism; Chemistry; Helix (gastropod); Dimer; Crystallography; Intramolecular force; Denaturation (fissile materials); Protein secondary structure; Guanidine; Helix bundle; Protein structure; Biophysics; Stereochemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001797095,0.0004494448,0.0002610096,0.0001171654,0.0001164119,0.000225532,0.0002624452,0.0001996985,0.0005354089],"category_scores_gemma":[0.000144885,0.0001454605,0.0003631645,0.0001637571,0.0002039234,0.0001281761,0.000214245,0.0003527793,0.0005296557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003334405,"about_ca_system_score_gemma":0.0002741526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004423861,"about_ca_topic_score_gemma":0.0005844125,"domain_scores_codex":[0.9998556,0.00002272466,0.00002017308,0.00003071379,0.00004984374,0.00002099588],"domain_scores_gemma":[0.9998711,0.0000158572,0.00003893916,0.00002313515,0.00002082447,0.00003005411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006222672,0.00002023952,0.0001752084,0.00001293807,0.00000577298,0.00005687223,0.000004217256,0.00006721784,0.998955,0.00002842607,0.00001656619,0.0005953016],"study_design_scores_gemma":[0.00003428461,0.0003501392,0.003334044,0.000004391778,0.00003569576,0.0007846634,0.00001367639,0.001095054,0.9915398,0.00003045938,0.002771535,0.000006253976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919281,0.0006211693,0.006063441,0.00005267702,0.0000284383,0.00007858868,0.0004089411,0.00006341071,0.0007552177],"genre_scores_gemma":[0.9787204,0.0004293227,0.01687605,0.00007048402,0.00001792947,0.00006476279,0.001474055,0.00002354787,0.00232329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005354089,"threshold_uncertainty_score":0.002419293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209433750192773,"score_gpt":0.2454046787436997,"score_spread":0.2333103412417719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}