{"id":"W2003574986","doi":"10.1371/journal.pone.0072776","title":"Eight Nucleotide Substitutions Inhibit Splicing to HPV-16 3′-Splice Site SA3358 and Reduce the Efficiency by which HPV-16 Increases the Life Span of Primary Human Keratinocytes","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Technological University Dublin; Vetenskapsrådet; Uppsala Universitet; University of Toronto; Cancerfonden","keywords":"Enhancer; RNA splicing; Biology; Alternative splicing; Gene; Exonic splicing enhancer; Genetics; Molecular biology; Gene expression; RNA; Messenger RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000422935,0.0002050541,0.0004373556,0.0001015967,0.0005493485,0.00008362596,0.0002719818,0.0000759814,0.00312323],"category_scores_gemma":[0.0006633612,0.0001229374,0.00006159736,0.0006313093,0.0003315242,0.0001328949,0.0002681528,0.0004453154,0.0001257966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001463473,"about_ca_system_score_gemma":0.0001716186,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007711653,"about_ca_topic_score_gemma":0.001006392,"domain_scores_codex":[0.9979155,0.0001187726,0.000410389,0.0003849339,0.0007394868,0.0004308927],"domain_scores_gemma":[0.9979857,0.0004147913,0.00009184736,0.0006362062,0.000501514,0.0003699742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004353971,0.003975365,0.0403882,0.001283311,0.0005194102,0.000005108901,0.002616439,0.00001371949,0.9045002,0.001437355,0.03764251,0.007182927],"study_design_scores_gemma":[0.002300791,0.0009852822,0.7628433,0.0003652246,0.0007413763,0.00001705865,0.0009151899,0.0004872511,0.2292044,0.0002058127,0.001489224,0.0004450963],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9630903,0.002547094,0.00003592549,0.007727492,0.00001109407,0.001412203,0.00004926238,0.0000475415,0.02507907],"genre_scores_gemma":[0.9962959,0.0003043609,0.0001433146,0.001891972,0.0003008439,0.0001482872,0.00008000185,0.00003013197,0.0008052046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.722455,"threshold_uncertainty_score":0.9988961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0435688568253176,"score_gpt":0.2764688908249363,"score_spread":0.2329000339996187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}