{"id":"W2003574986","doi":"10.1371/journal.pone.0072776","title":"Eight Nucleotide Substitutions Inhibit Splicing to HPV-16 3′-Splice Site SA3358 and Reduce the Efficiency by which HPV-16 Increases the Life Span of Primary Human Keratinocytes","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Technological University Dublin; Vetenskapsrådet; Uppsala Universitet; University of Toronto; Cancerfonden","keywords":"Enhancer; RNA splicing; Biology; Alternative splicing; Gene; Exonic splicing enhancer; Genetics; Molecular biology; Gene expression; RNA; Messenger RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001867975,0.0003852797,0.0003364721,0.0001382294,0.0001441582,0.0002302247,0.0002698985,0.0002666558,0.00218984],"category_scores_gemma":[0.0001781733,0.0001998467,0.0003482292,0.0001317331,0.0002461472,0.0001112313,0.000184006,0.0005539092,0.0005833527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002017942,"about_ca_system_score_gemma":0.0002637898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006167317,"about_ca_topic_score_gemma":0.0008753322,"domain_scores_codex":[0.9997641,0.00004673526,0.00005248147,0.0000411339,0.000055074,0.0000405432],"domain_scores_gemma":[0.9997321,0.00008404387,0.00006762183,0.00005159279,0.00001694865,0.0000477699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001130973,0.00008129934,0.0001956212,0.00002184579,0.00000644432,0.00003511291,0.00001344471,0.00006184096,0.9983678,0.00006297323,0.00001640319,0.00102419],"study_design_scores_gemma":[0.00001531654,0.0004991527,0.002067793,0.00000434111,0.00001543155,0.0002045773,0.00001637143,0.0003704172,0.9958442,0.00001890009,0.0009405229,0.000002983484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981794,0.0003436594,0.0007641291,0.0000253483,0.00002248086,0.00002079764,0.0001133954,0.00003203488,0.0004987261],"genre_scores_gemma":[0.996491,0.0003623572,0.001444456,0.00003284123,0.000007113205,0.0000308333,0.0004313439,0.00002574254,0.001174197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00218984,"threshold_uncertainty_score":0.007325768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0435688568253176,"score_gpt":0.2764688908249363,"score_spread":0.2329000339996187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}