{"id":"W2003583816","doi":"10.1016/j.biochi.2012.06.021","title":"In vitro activity of human translation initiation factor eIF4B is not affected by phosphomimetic amino acid substitutions S422D and S422E","year":2012,"lang":"en","type":"article","venue":"Biochimie","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Russian Foundation for Basic Research; McGill University; Yale University","keywords":"Eukaryotic initiation factor; Initiation factor; Eukaryotic translation; Chemistry; Translation (biology); Phosphorylation; Protein biosynthesis; In vitro; Biochemistry; Cell biology; Molecular biology; Messenger RNA; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001307063,0.0001344792,0.0001498162,0.00005602691,0.00006572904,0.00001056178,0.00006840123,0.0001869135,0.00003773815],"category_scores_gemma":[0.00003146072,0.0001352254,0.00005367034,0.00008154607,0.00005946226,0.00001914735,0.00002050064,0.00005728494,0.000003563916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001312302,"about_ca_system_score_gemma":0.00001986338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004083104,"about_ca_topic_score_gemma":0.000009261681,"domain_scores_codex":[0.9992607,0.00008690016,0.0001592838,0.0001991537,0.000102157,0.0001917764],"domain_scores_gemma":[0.9996282,0.00001423609,0.00009469306,0.0001738013,0.00002428948,0.00006480573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009353554,0.0001704297,0.0003949129,0.00002224757,0.00001706115,1.421446e-7,0.0001511356,8.473636e-8,0.9948676,0.00003635396,0.00004994755,0.004196515],"study_design_scores_gemma":[0.0005293319,0.000100279,0.01921923,0.000009208269,0.00001918637,0.000001643117,0.00001059481,0.000007182103,0.9795891,0.0000272199,0.0003407923,0.000146217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964938,0.001119016,0.001645689,0.00008779897,0.00008557642,0.0002518694,0.0001320755,0.00000817509,0.0001760455],"genre_scores_gemma":[0.9991254,0.00009369028,0.0004460569,0.00008066055,0.00006260405,0.00002733334,0.000100593,0.00001321472,0.00005044076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01882432,"threshold_uncertainty_score":0.5514331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02458225286193769,"score_gpt":0.2654778186732485,"score_spread":0.2408955658113109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}