{"id":"W2003605294","doi":"10.2353/ajpath.2007.060860","title":"Relative Reduction of Endothelial Nitric-Oxide Synthase Expression and Transcription in Atherosclerosis-Prone Regions of the Mouse Aorta and in an in Vitro Model of Disturbed Flow","year":2007,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Toronto General Hospital; University of Toronto","funders":"Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"In vitro; Nitric oxide synthase; Endothelial nitric oxide synthase; Aorta; Transcription (linguistics); Nitric oxide; Endothelium; Cell biology; Biology; Pathology; Biochemistry; Medicine; Genetics; Internal medicine; Endocrinology; Enos","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003194313,0.0006384651,0.0005071872,0.0008839996,0.0003099163,0.0005157765,0.0002302201,0.0005194388,0.001731765],"category_scores_gemma":[0.0002102526,0.000557005,0.0004754023,0.0003190305,0.000562404,0.0004303926,0.0002821726,0.001119846,0.0002758777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002701823,"about_ca_system_score_gemma":0.0002010588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000637068,"about_ca_topic_score_gemma":0.00103477,"domain_scores_codex":[0.9997347,0.00004289381,0.00002591975,0.00007680062,0.00005580861,0.00006392866],"domain_scores_gemma":[0.9995128,0.00006438106,0.0001087474,0.00006062489,0.00004745043,0.0002059881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001897458,0.00002131351,0.0001074347,0.00001730938,0.000004316426,0.00002321466,0.0000204126,0.0000133666,0.9993327,0.00008528966,0.000008748332,0.0001760702],"study_design_scores_gemma":[0.00003830428,0.0003720581,0.01357166,0.00001003677,0.00006133342,0.0002599981,0.0001038005,0.0004856287,0.9842634,0.0001348677,0.0006901679,0.000008829691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941204,0.001448629,0.003013005,0.00009352987,0.00004864599,0.00001262116,0.0003920562,0.00008191303,0.0007891685],"genre_scores_gemma":[0.9862555,0.001333651,0.003475463,0.00009929532,0.00003740405,0.00008386572,0.0008494362,0.00005683553,0.007808552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001731765,"threshold_uncertainty_score":0.005793273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01912080416484813,"score_gpt":0.2710666484058794,"score_spread":0.2519458442410312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}