{"id":"W2003605294","doi":"10.2353/ajpath.2007.060860","title":"Relative Reduction of Endothelial Nitric-Oxide Synthase Expression and Transcription in Atherosclerosis-Prone Regions of the Mouse Aorta and in an in Vitro Model of Disturbed Flow","year":2007,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Toronto General Hospital; University of Toronto","funders":"Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"In vitro; Nitric oxide synthase; Endothelial nitric oxide synthase; Aorta; Transcription (linguistics); Nitric oxide; Endothelium; Cell biology; Biology; Pathology; Biochemistry; Medicine; Genetics; Internal medicine; Endocrinology; Enos","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008155296,0.0001007627,0.0005415389,0.0004077992,0.0000124962,0.000001057209,0.00006184539,0.00007130872,7.805672e-7],"category_scores_gemma":[0.0001977222,0.00007209126,0.00005999391,0.0003248307,0.0004343805,0.0001209614,0.00001463953,0.0003103816,2.534852e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004611519,"about_ca_system_score_gemma":0.00004945798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001352578,"about_ca_topic_score_gemma":0.00003863267,"domain_scores_codex":[0.9986296,0.000293443,0.0006514527,0.000132711,0.0001478573,0.000144962],"domain_scores_gemma":[0.9990034,0.0001493168,0.0005707071,0.0001464118,0.00007015233,0.00006006545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002907126,0.0003433513,0.02613266,0.00003200018,0.000008141346,0.00002477469,0.002942587,0.0004029641,0.9626914,0.00001335303,7.308592e-7,0.004500862],"study_design_scores_gemma":[0.005090558,0.001140167,0.2217864,0.0004210094,0.00007977011,0.000322022,0.003594096,0.001739004,0.7652661,0.0004715732,5.614641e-7,0.00008870027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971811,0.0001456782,0.002330179,0.00009129255,0.00002296281,0.0001962863,0.00001605278,0.000001678648,0.00001481824],"genre_scores_gemma":[0.993915,0.0002597439,0.005762083,0.0000200845,0.00001913413,0.000002832058,0.000001344514,0.00001140635,0.000008363335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1974253,"threshold_uncertainty_score":0.2939796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01912080416484813,"score_gpt":0.2710666484058794,"score_spread":0.2519458442410312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}