{"id":"W2003617014","doi":"10.1016/j.bbadis.2013.04.018","title":"IGF-II and IGFBP-6 regulate cellular contractility and proliferation in Dupuytren's disease","year":2013,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Dupuytren's Contracture and Treatments","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Hand and Upper Limb Clinic; Lawson Health Research Institute","funders":"Canadian Institutes of Health Research; Plastic Surgery Foundation","keywords":"Contractility; Growth factor; Cell biology; Biology; Cell growth; Internal medicine; Endocrinology; Chemistry; Medicine; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001889759,0.0002516086,0.0002893095,0.00058099,0.0002876277,0.0004785572,0.00013687,0.0002806808,0.0009561116],"category_scores_gemma":[0.0002664908,0.0001986426,0.0001844262,0.0002174969,0.000316852,0.0001960157,0.0001788401,0.0004218881,0.0001064221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004345425,"about_ca_system_score_gemma":0.0001290723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002624327,"about_ca_topic_score_gemma":0.001823252,"domain_scores_codex":[0.9999082,0.00002517126,0.000009129441,0.00001049666,0.00002336243,0.00002361292],"domain_scores_gemma":[0.9999073,0.00002419355,0.00002064852,0.00000497607,0.00001001124,0.00003288686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005598628,0.0001207375,0.02759639,0.0001323613,0.00006057415,0.001577244,0.0004570539,0.0004915621,0.941168,0.0007018638,0.0003024753,0.02179313],"study_design_scores_gemma":[0.0002314068,0.001446992,0.7582846,0.00004158687,0.0001878892,0.003620643,0.001016311,0.003522226,0.2251697,0.0008997653,0.00552683,0.00005209153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903768,0.007112479,0.0007290093,0.0001251754,0.000036721,0.000007085922,0.0001185261,0.00002474598,0.001469544],"genre_scores_gemma":[0.9980361,0.0008229836,0.000318779,0.00002490744,0.00001920874,0.000008402426,0.00005033596,0.000003111647,0.0007163139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002624327,"threshold_uncertainty_score":0.005218089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005072130847140125,"score_gpt":0.2279390822728352,"score_spread":0.222866951425695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}