{"id":"W2003631713","doi":"10.1002/ijc.25191","title":"Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin","year":2010,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":332,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Alberta Heritage Foundation for Medical Research; Natural Sciences and Engineering Research Council of Canada; Alberta Health Services","keywords":"microRNA; Cisplatin; Cancer research; MCF-7; Biology; Breast cancer; Cancer; Downregulation and upregulation; Cancer cell; Phenotype; DNA methylation; Chemotherapy; Gene expression; Gene; Human breast; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001086667,0.0001868502,0.0002399608,0.0003449928,0.0001213456,0.00025899,0.00007803896,0.0001776823,0.0006285222],"category_scores_gemma":[0.000312001,0.0002010659,0.0001442929,0.000232957,0.0001443742,0.0001180686,0.0001268798,0.0002818838,0.0001953146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001846431,"about_ca_system_score_gemma":0.0001388836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002676935,"about_ca_topic_score_gemma":0.0003877871,"domain_scores_codex":[0.9998314,0.00002466286,0.00002134006,0.00002913648,0.00006723992,0.00002612966],"domain_scores_gemma":[0.9998389,0.00002792627,0.00007064325,0.00001343481,0.00002866909,0.00002031013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000109181,0.00001438611,0.003978728,0.00002763307,0.00001241827,0.0001822597,0.00003446063,0.00005458324,0.9939406,0.00005632057,0.0000473564,0.001542177],"study_design_scores_gemma":[0.00001833923,0.0003730999,0.2233221,0.00001182091,0.00008717365,0.00353218,0.0001298066,0.001135014,0.7673617,0.0001533738,0.003859685,0.00001573106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969627,0.001288827,0.0008008768,0.00004408563,0.0000076532,0.000008314096,0.0001835052,0.00002727047,0.0006766891],"genre_scores_gemma":[0.9975058,0.0006760786,0.000838104,0.00002765486,0.000005190513,0.00001990655,0.0003237163,0.000005551211,0.0005979488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006285222,"threshold_uncertainty_score":0.002102673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00480420866955217,"score_gpt":0.255387561237374,"score_spread":0.2505833525678218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}