{"id":"W2003644785","doi":"10.3346/jkms.2005.20.4.548","title":"Epigallocatechin-3-gallate Suppresses Galactose-α1,4-galactose-β1,4-glucose Ceramide Expression in TNF-α Stimulated Human Intestinal Epithelial Cells Through Inhibition of MAPKs and NF-κB","year":2005,"lang":"en","type":"article","venue":"Journal of Korean Medical Science","topic":"Tea Polyphenols and Effects","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Korea Science and Engineering Foundation; University of Toronto; Pusan National University Hospital; Pusan National University","keywords":"Ceramide; Lactosylceramide; Tumor necrosis factor alpha; Chemistry; NF-κB; Ceramide synthase; Kinase; Molecular biology; Signal transduction; Biology; Biochemistry; Apoptosis; Endocrinology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009270296,0.0004235331,0.0002651982,0.0001962966,0.0001140461,0.000209192,0.0001319403,0.0001925447,0.0008146263],"category_scores_gemma":[0.00009310686,0.000115827,0.0003618456,0.0001219465,0.000204412,0.0001390343,0.0001486812,0.0005147529,0.0002478969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000142341,"about_ca_system_score_gemma":0.0001997861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007720425,"about_ca_topic_score_gemma":0.00106407,"domain_scores_codex":[0.99992,0.00001561628,0.000009344195,0.00001015571,0.00001559428,0.0000293193],"domain_scores_gemma":[0.9999404,0.000008030443,0.00001551562,0.000007997542,0.000008965607,0.00001918547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007347721,0.00008771774,0.0001470497,0.00007443252,0.00001036106,0.00005418976,0.00002366867,0.00004064033,0.9976934,0.000020877,0.00003495452,0.001078003],"study_design_scores_gemma":[0.00009415334,0.001611553,0.009073423,0.00001482586,0.00005228023,0.0002511254,0.00007172015,0.0006882417,0.9864441,0.00005128053,0.001641654,0.000005486521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959098,0.002425149,0.0005902618,0.0001231566,0.00003913204,0.00001814868,0.0001615719,0.0000589173,0.0006737868],"genre_scores_gemma":[0.9959334,0.001242989,0.0004766421,0.00009527708,0.00001358625,0.00002926357,0.0002875097,0.0000106518,0.001910902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008146263,"threshold_uncertainty_score":0.002725184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01697596484923384,"score_gpt":0.3033264839597644,"score_spread":0.2863505191105306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}