{"id":"W2003693067","doi":"10.1038/cddis.2013.413","title":"Small molecule sensitization to TRAIL is mediated via nuclear localization, phosphorylation and inhibition of chaperone activity of Hsp27","year":2013,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Biomedical Research Council; National Medical Research Council; Medical Research Council; Ministry of Education, India; Ministry of Earth Sciences; National University of Singapore","keywords":"Hsp27; Cell biology; Phosphorylation; p38 mitogen-activated protein kinases; Kinase; Apoptosis; Chemistry; Cytosol; Biology; Heat shock protein; Protein kinase A; Cancer research; Biochemistry; Hsp70; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007624427,0.0002242874,0.0002479294,0.0001142223,0.0001069828,0.0001800622,0.0001210822,0.000106561,0.0009425068],"category_scores_gemma":[0.00007211309,0.0000780694,0.0002166766,0.0001235043,0.0001977112,0.0001166558,0.000139665,0.000363212,0.0002987956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002427424,"about_ca_system_score_gemma":0.0002165063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003500089,"about_ca_topic_score_gemma":0.0005920685,"domain_scores_codex":[0.9999377,0.00001006825,0.000006000162,0.00001289853,0.00001839111,0.00001500187],"domain_scores_gemma":[0.9999428,0.0000116287,0.00001677586,0.00001099022,0.000007610684,0.00001012794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007239659,0.00001378406,0.00006844149,0.00002471217,0.000003155676,0.00002991427,0.000006367428,0.00006358809,0.9988397,0.00005973359,0.00001809407,0.0008000838],"study_design_scores_gemma":[0.000008055085,0.0002226652,0.0014157,0.000002112795,0.000005458312,0.0001217414,0.000009134958,0.0002373178,0.9971347,0.00002289655,0.0008182676,0.000001821103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923785,0.001972019,0.004042872,0.00007981242,0.00001746746,0.00004438986,0.0002640589,0.00009220495,0.001108595],"genre_scores_gemma":[0.9964773,0.001178097,0.0009230618,0.00002157527,0.000004953792,0.00003082024,0.0002337046,0.000008498787,0.001121988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009425068,"threshold_uncertainty_score":0.003152966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009773976921053171,"score_gpt":0.2195646134837932,"score_spread":0.2097906365627401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}