{"id":"W2003701881","doi":"10.1158/0008-5472.can-04-2369","title":"Mitogen- and Stress-Activated Protein Kinase 1 Activity and Histone H3 Phosphorylation in Oncogene-Transformed Mouse Fibroblasts","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Histone H3; Protein kinase A; c-Raf; Mitogen-activated protein kinase; Mitogen-activated protein kinase kinase; MAPK/ERK pathway; Cell biology; Kinase; Signal transduction; MAP kinase kinase kinase; Mitogen-Activated Protein Kinase 3; Molecular biology; MAP2K7; ASK1; Biology; Chemistry; Chromatin; Cyclin-dependent kinase 2; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000175221,0.0005430246,0.0002151138,0.0005793535,0.0002324052,0.0002869733,0.0003137501,0.0003644809,0.001696075],"category_scores_gemma":[0.0001073044,0.0003149348,0.0004235279,0.000314704,0.00023486,0.0001961819,0.000171027,0.000767008,0.0006215703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004879859,"about_ca_system_score_gemma":0.0002421165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00228864,"about_ca_topic_score_gemma":0.00286657,"domain_scores_codex":[0.9997672,0.00002997983,0.00003030604,0.00004498347,0.0000750647,0.0000524327],"domain_scores_gemma":[0.9998125,0.00002665468,0.00004930115,0.00002556934,0.00001816601,0.0000677876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001050922,0.00002917158,0.0001860005,0.00001075017,0.000002829021,0.00005297219,0.00001304319,0.00002412006,0.9992218,0.00005358224,0.00001455828,0.0002861187],"study_design_scores_gemma":[0.00002828007,0.0003145795,0.01085151,0.000004151134,0.00001235085,0.000401304,0.00003855413,0.0008038494,0.9861853,0.00006145534,0.001291525,0.000007143921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945215,0.001321544,0.001437553,0.00007420919,0.00003156749,0.0000305668,0.00103572,0.0001128208,0.00143456],"genre_scores_gemma":[0.9899525,0.001130107,0.002378728,0.000036609,0.00001168111,0.00007732509,0.0016749,0.00002531989,0.004712931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00228864,"threshold_uncertainty_score":0.005673945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.031506656332913,"score_gpt":0.3431884818826738,"score_spread":0.3116818255497608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}