{"id":"W2003716334","doi":"10.1016/j.placenta.2005.09.001","title":"Designing Pregnancy Centered Medications: Drugs Which Do Not Cross the Human Placenta","year":2005,"lang":"en","type":"review","venue":"Placenta","topic":"Pregnancy and Medication Impact","field":"Medicine","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"","keywords":"Placenta; Abcg2; Pregnancy; Medicine; Drugs in pregnancy; Pharmacology; Drug; Transporter; Efflux; P-glycoprotein; Fetus; Drug resistance; Bioinformatics; Multiple drug resistance; ATP-binding cassette transporter; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009818672,0.0007782975,0.001735341,0.0002894105,0.0006232179,0.0001590442,0.00106793,0.0006021918,0.001412346],"category_scores_gemma":[0.0006692129,0.0005082639,0.0005756441,0.0007195608,0.0003237757,0.0002278076,0.0002403394,0.001490708,0.0006920894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006306323,"about_ca_system_score_gemma":0.001310392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002546145,"about_ca_topic_score_gemma":0.00001374426,"domain_scores_codex":[0.9951657,0.000459098,0.001463307,0.0009106915,0.00112062,0.0008805644],"domain_scores_gemma":[0.9956783,0.0006412868,0.001016213,0.001871648,0.000195719,0.0005968144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004230705,0.0004842084,0.000188211,0.01084531,0.0008434415,0.00002644428,0.001565323,7.335934e-7,0.000008197397,0.0002861525,0.01965657,0.9660531],"study_design_scores_gemma":[0.001768049,0.000061475,0.0001124117,0.1031589,0.002153745,0.0002645974,0.0001604768,0.00000666419,0.00003065926,0.000008706525,0.8918453,0.0004290631],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001210964,0.9861882,0.0001448216,0.001335671,0.0006737657,0.003327462,0.0001883298,0.0002313311,0.007898351],"genre_scores_gemma":[0.0006407818,0.9881436,0.0002639468,0.0005965256,0.0009362689,0.0007117739,0.001334706,0.0001452271,0.007227154],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.965624,"threshold_uncertainty_score":0.9997369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0963134162695634,"score_gpt":0.4168699834152314,"score_spread":0.320556567145668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}