{"id":"W2003731708","doi":"10.1016/j.tetlet.2011.01.089","title":"One-pot multistep synthesis of 3,4-fused isoquinolin-1(2H)-one analogs","year":2011,"lang":"en","type":"article","venue":"Tetrahedron Letters","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Benzonitrile; Substituent; Alkylation; Yield (engineering); Deprotonation; Atropisomer; Aryl; Alkyl; Product (mathematics); Cascade; Combinatorial chemistry; Stereochemistry; Medicinal chemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002610642,0.0003327692,0.0007050297,0.0003404493,0.00009041037,0.00002146808,0.0006925983,0.0002176771,0.002893697],"category_scores_gemma":[0.0003170064,0.0003605591,0.000400612,0.0005314592,0.0002496444,0.0001485913,0.00009611798,0.0002424085,0.0002074617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001289909,"about_ca_system_score_gemma":0.00002907748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007601547,"about_ca_topic_score_gemma":0.00002986353,"domain_scores_codex":[0.9975609,0.00004912808,0.000699798,0.0005764979,0.0005600874,0.0005535501],"domain_scores_gemma":[0.9979392,0.0004072052,0.0003891001,0.001021892,0.00006664255,0.0001759778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002144185,0.001278423,0.02100727,0.0004696065,0.001204349,0.00004237976,0.001135109,0.000006188932,0.7114488,0.0002460997,0.00179594,0.2611513],"study_design_scores_gemma":[0.0005226503,0.00003540704,0.01845384,0.0001359772,0.0004611037,0.000005489444,0.0003549994,0.00007393794,0.978644,0.00003729777,0.000755651,0.0005196134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9251685,0.0002889297,0.0008865229,0.0004431779,0.0001096669,0.0001133999,0.00009083335,0.000218229,0.07268075],"genre_scores_gemma":[0.9950595,0.00006310914,0.003911661,0.0003836511,0.0001479795,0.00004535221,0.00002064821,0.00006973249,0.0002983939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2671952,"threshold_uncertainty_score":0.9998847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03717980736636198,"score_gpt":0.2141450061678984,"score_spread":0.1769651988015364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}