{"id":"W2003742961","doi":"10.1371/journal.pone.0049763","title":"Novel MeCP2 Isoform-Specific Antibody Reveals the Endogenous MeCP2E1 Expression in Murine Brain, Primary Neurons and Astrocytes","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institutes of Health; Hospital for Sick Children; Scottish Rite Charitable Foundation of Canada; Manitoba Health Research Council; Health Sciences Centre Foundation","keywords":"MECP2; Gene isoform; Endogeny; Biology; Rett syndrome; Gene expression; Cell biology; Molecular biology; Astrocyte; Neuroscience; Gene; Central nervous system; Genetics; Phenotype; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000161931,0.0001724793,0.0001625079,0.00004194245,0.000107728,0.0000225771,0.0001735003,0.00007577326,0.00001626919],"category_scores_gemma":[0.00004579675,0.0001369687,0.00003408751,0.00007935349,0.00006710999,0.000008111313,0.0002664864,0.0001178663,0.000007195198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009705776,"about_ca_system_score_gemma":0.00001968286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003837402,"about_ca_topic_score_gemma":0.0000054216,"domain_scores_codex":[0.9989119,0.00004670601,0.0002083098,0.0002811205,0.0001782173,0.0003737912],"domain_scores_gemma":[0.9994972,0.00002919528,0.00006449666,0.0002878947,0.00002811878,0.00009312113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004387721,0.0007136189,0.01704847,0.00003424984,0.00002479667,0.000001032087,0.0001064064,0.000001876819,0.9814703,0.00001159946,0.0002627056,0.0002810545],"study_design_scores_gemma":[0.0005341842,0.0001321236,0.2914397,0.00003331487,0.00001137732,0.00001831469,0.00005795597,0.000003640813,0.7059007,0.00000824834,0.001702704,0.0001577977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950408,0.003391588,0.0001112541,0.0003048328,0.00004221069,0.0003281775,0.00001928083,0.000009250815,0.0007526047],"genre_scores_gemma":[0.9943392,0.002194658,0.002211659,0.0007663921,0.0000570472,0.00003342244,0.0001081268,0.00003040626,0.0002590608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2755696,"threshold_uncertainty_score":0.5585423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03506581111479939,"score_gpt":0.2236861100865066,"score_spread":0.1886202989717072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}