{"id":"W2003787288","doi":"10.1038/sj.onc.1211031","title":"Low-dose metronomic cyclophosphamide treatment mediates ischemia-dependent K-ras mutation in colorectal carcinoma xenografts","year":2008,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Children's Hospital; University of Guelph","funders":"National Cancer Institute","keywords":"Cancer research; Biology; Colorectal cancer; Oncogene; Cyclophosphamide; Hypoxia (environmental); Tumor hypoxia; Cancer; Tumor progression; Pharmacology; Immunology; Internal medicine; Chemotherapy; Medicine; Cell cycle; Radiation therapy; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001969417,0.0002974753,0.0004538032,0.0003830155,0.0002939709,0.0003184188,0.0003718313,0.0003655128,0.001639645],"category_scores_gemma":[0.0001790512,0.0002229882,0.0002779751,0.0002775341,0.0003026275,0.0002836412,0.000151793,0.0009146206,0.0003094333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005303199,"about_ca_system_score_gemma":0.0003841294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002364219,"about_ca_topic_score_gemma":0.004101982,"domain_scores_codex":[0.9998053,0.00003663476,0.00001517786,0.00002855677,0.00003534923,0.00007906281],"domain_scores_gemma":[0.9997986,0.00005538001,0.00004464063,0.00003168594,0.00001171003,0.0000580372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001301748,0.0003609497,0.0002781407,0.00003515805,0.00001162691,0.0001098442,0.00003266042,0.0001888762,0.9957236,0.0002777892,0.0001993762,0.001480183],"study_design_scores_gemma":[0.0001298035,0.002179046,0.004192097,0.000005122213,0.00002394914,0.0002423745,0.00004452321,0.001444793,0.9905964,0.0000736471,0.00106177,0.000006492125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971519,0.0006225292,0.0005256583,0.0001286906,0.00004062547,0.00003860225,0.000358979,0.00006682995,0.001066167],"genre_scores_gemma":[0.9975027,0.0002586145,0.0004356374,0.00002504235,0.00001057754,0.00004000665,0.0003683962,0.00001506643,0.001343766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002364219,"threshold_uncertainty_score":0.005485117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009265366578996782,"score_gpt":0.2347268545813896,"score_spread":0.2254614880023929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}