{"id":"W2003799938","doi":"10.1021/bi047327n","title":"Ku80 Binds to Human Replication Origins Prior to the Assembly of the ORC Complex","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Ku80; Chromatin immunoprecipitation; Immunoprecipitation; Biology; Chromatin; Molecular biology; Origin recognition complex; Protein subunit; DNA replication; Cell biology; Cell culture; DNA; DNA-binding protein; Gene; Genetics; Eukaryotic DNA replication; Promoter; Transcription factor; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002329035,0.0001465527,0.0001091649,0.00001510971,0.0001339255,0.0000198746,0.0007114201,0.0001299424,0.00003210245],"category_scores_gemma":[0.0001465909,0.0001006704,0.0001076497,0.0001707071,0.00004397679,0.000001808637,0.0003078901,0.00007456361,0.00003143999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005760415,"about_ca_system_score_gemma":0.00008022809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001817883,"about_ca_topic_score_gemma":0.00002996069,"domain_scores_codex":[0.9988952,0.0000280042,0.0002301036,0.0004370922,0.0002005975,0.0002089821],"domain_scores_gemma":[0.9980368,0.000006748441,0.0001043252,0.001648107,0.0001080889,0.00009591413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001550801,0.00004708108,0.0001566005,0.00001183953,0.00001809157,1.201524e-7,0.00003702832,0.00002608027,0.9821544,0.0001434667,0.015613,0.001776829],"study_design_scores_gemma":[0.0001255765,0.00005800763,0.001630843,0.00001181326,0.0000114014,0.000006136701,0.0000301361,0.00001898936,0.8385479,0.000006483624,0.159438,0.0001146782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994269,0.00005125955,0.0003101285,0.002891108,0.00006271495,0.0003262046,0.00003570596,0.00002050287,0.00203344],"genre_scores_gemma":[0.9929757,0.000003073034,0.001615069,0.001242113,0.0004211761,0.00005990447,0.00005621421,0.0000223722,0.003604386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.143825,"threshold_uncertainty_score":0.410522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0182955630170604,"score_gpt":0.2904940480581549,"score_spread":0.2721984850410945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}