{"id":"W2003799938","doi":"10.1021/bi047327n","title":"Ku80 Binds to Human Replication Origins Prior to the Assembly of the ORC Complex","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Ku80; Chromatin immunoprecipitation; Immunoprecipitation; Biology; Chromatin; Molecular biology; Origin recognition complex; Protein subunit; DNA replication; Cell biology; Cell culture; DNA; DNA-binding protein; Gene; Genetics; Eukaryotic DNA replication; Promoter; Transcription factor; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001321262,0.0004471049,0.0003184923,0.0002833998,0.0002974297,0.0005490439,0.0002358804,0.000287343,0.002373187],"category_scores_gemma":[0.0002397845,0.0002738065,0.0002938425,0.0002030779,0.0002132844,0.0002764245,0.000460203,0.0004219724,0.0009576858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007352536,"about_ca_system_score_gemma":0.0002908882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00264931,"about_ca_topic_score_gemma":0.003122317,"domain_scores_codex":[0.9995925,0.00003510103,0.00002309362,0.0001595149,0.0001035696,0.000086224],"domain_scores_gemma":[0.9998109,0.00001450172,0.00005427174,0.00003156412,0.00003776297,0.00005108326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009279896,0.000005928242,0.0008814947,0.00002971095,0.000006487026,0.00004245819,0.00001807132,0.00002297154,0.9980727,0.00004401458,0.00004759257,0.0007355624],"study_design_scores_gemma":[0.00001294963,0.0001014474,0.06082364,0.00001796351,0.00002001209,0.0003628198,0.00006630195,0.0005562133,0.9318563,0.00003860917,0.006134452,0.000009205233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991956,0.003789956,0.002011945,0.00007741873,0.00002630982,0.00001543687,0.0003334516,0.00008959309,0.001699999],"genre_scores_gemma":[0.992382,0.0008060659,0.001351029,0.00008578223,0.00001434017,0.0000170657,0.001092214,0.00004236371,0.004209156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00264931,"threshold_uncertainty_score":0.0079391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0182955630170604,"score_gpt":0.2904940480581549,"score_spread":0.2721984850410945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}