{"id":"W2003822145","doi":"10.1016/j.jmb.2008.09.025","title":"Biochemical and Structural Characterization of an Intramolecular Interaction in FOXO3a and Its Binding with p53","year":2008,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Transactivation; Binding site; Transcription factor; Linker; Forkhead Transcription Factors; DNA; Intramolecular force; Cooperative binding; Chemistry; Subfamily; Plasma protein binding; DNA-binding domain; Binding domain; Allosteric regulation; DNA binding site; Biophysics; Biology; Biochemistry; Stereochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000105653,0.0001104505,0.0001826642,0.0001541465,0.00002311578,0.000006579458,0.00006464874,0.0001468991,0.000002999074],"category_scores_gemma":[0.00003881216,0.00009344818,0.00003228463,0.00008148388,0.0001054246,0.00001828883,0.0000160845,0.0001109025,1.021167e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001194961,"about_ca_system_score_gemma":0.00003384973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003239751,"about_ca_topic_score_gemma":0.00000297498,"domain_scores_codex":[0.9992528,0.00009980608,0.0002979525,0.0001642082,0.00007650759,0.0001087346],"domain_scores_gemma":[0.9994838,0.000004950728,0.0002403462,0.0000801646,0.0001287583,0.00006201734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003129512,0.00002317983,0.0069891,0.00001476248,0.00003517239,0.00001802832,0.00007043429,0.00002348801,0.9919206,0.0000629179,5.373641e-7,0.0005288414],"study_design_scores_gemma":[0.0008960784,0.0009823038,0.04291658,0.00002792153,0.00001692698,0.0009997116,0.00002669091,0.0001995717,0.9537349,0.0000334706,0.00006377089,0.0001020876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971545,0.0003487339,0.00227664,0.00005937654,0.00005976941,0.00008692151,0.000006743076,0.000001701651,0.000005605358],"genre_scores_gemma":[0.9989285,0.000164184,0.0007436014,0.00003616804,0.00003728834,0.000001190742,0.00007530257,0.00001152936,0.000002162935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0381857,"threshold_uncertainty_score":0.3810706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008420272918422967,"score_gpt":0.2504389453332137,"score_spread":0.2420186724147907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}