{"id":"W2003822145","doi":"10.1016/j.jmb.2008.09.025","title":"Biochemical and Structural Characterization of an Intramolecular Interaction in FOXO3a and Its Binding with p53","year":2008,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Transactivation; Binding site; Transcription factor; Linker; Forkhead Transcription Factors; DNA; Intramolecular force; Cooperative binding; Chemistry; Subfamily; Plasma protein binding; DNA-binding domain; Binding domain; Allosteric regulation; DNA binding site; Biophysics; Biology; Biochemistry; Stereochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002215505,0.0002910985,0.0002443129,0.0001219387,0.0005851079,0.0002660519,0.0004421141,0.0003507419,0.002872891],"category_scores_gemma":[0.0003532643,0.0001599209,0.000624595,0.0002410434,0.0003372765,0.0002765658,0.0003319011,0.0009138845,0.0006383482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008695244,"about_ca_system_score_gemma":0.0003656892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002368865,"about_ca_topic_score_gemma":0.002414376,"domain_scores_codex":[0.9998852,0.00001367655,0.000006846364,0.00003330003,0.00002315027,0.00003786018],"domain_scores_gemma":[0.9997893,0.00003471426,0.00005490066,0.00002494617,0.0000232104,0.00007287326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005883918,0.0001274846,0.001252176,0.00005605967,0.0000439884,0.000269774,0.00005918371,0.0003195471,0.9945021,0.0008882303,0.0002245063,0.001668564],"study_design_scores_gemma":[0.00008708656,0.0002456348,0.01938696,0.00001903269,0.0000867966,0.0007744021,0.0001210492,0.004498291,0.9656516,0.0003835783,0.00872145,0.00002406527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933953,0.0009223691,0.002809993,0.0003520848,0.00006201916,0.00001825746,0.0003275252,0.0000442057,0.002068417],"genre_scores_gemma":[0.9954734,0.0002647062,0.001574379,0.0001098657,0.00001528974,0.00001561976,0.0006202543,0.00001690245,0.001909516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002872891,"threshold_uncertainty_score":0.009610772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008420272918422967,"score_gpt":0.2504389453332137,"score_spread":0.2420186724147907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}