{"id":"W2003850700","doi":"10.1006/mthe.2000.0206","title":"Evaluation of E1-Mutant Adenoviruses as Conditionally Replicating Agents for Cancer Therapy","year":2000,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McMaster University; McGill University","keywords":"Oncolytic virus; Cytopathic effect; Oncolytic adenovirus; In vivo; Biology; Mutant; In vitro; Cancer research; Cancer cell; Cancer; Growth inhibition; Virology; Tumor cells; Gene; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001154036,0.0002114804,0.0001967076,0.00006346117,0.0001102158,0.00002470966,0.0003437651,0.0001430695,0.001914624],"category_scores_gemma":[0.00006448934,0.0002006442,0.0001925562,0.0001511272,0.0001002042,0.000006267539,0.00001842482,0.00007604047,0.00001783841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004695105,"about_ca_system_score_gemma":0.0004412529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000041591,"about_ca_topic_score_gemma":0.00002039261,"domain_scores_codex":[0.9977899,0.0003156982,0.0003095233,0.0004975084,0.0007761358,0.0003112958],"domain_scores_gemma":[0.9985027,0.00002185047,0.000131458,0.0006232712,0.0006431955,0.00007755883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001859908,0.0001402007,0.000117404,0.000004648142,0.0003277128,7.304923e-7,0.00006485795,0.001037167,0.8019022,0.0000341081,0.0002255163,0.1942855],"study_design_scores_gemma":[0.003404556,0.001784878,0.0006142141,0.000015277,0.00002595971,0.000002944738,0.00001800684,0.0003189795,0.9644752,0.001063445,0.02805924,0.000217365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861782,0.01116751,0.0002362596,0.0003227114,0.00004379833,0.001258135,0.000102073,0.00001637892,0.0006749803],"genre_scores_gemma":[0.9916839,0.004530543,0.000155277,0.001930458,0.0001367997,0.0008821122,0.0002476062,0.00007196192,0.0003613334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1940681,"threshold_uncertainty_score":0.9989977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06880618687229809,"score_gpt":0.4018169728584107,"score_spread":0.3330107859861126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}