{"id":"W2003850700","doi":"10.1006/mthe.2000.0206","title":"Evaluation of E1-Mutant Adenoviruses as Conditionally Replicating Agents for Cancer Therapy","year":2000,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McMaster University; McGill University","keywords":"Oncolytic virus; Cytopathic effect; Oncolytic adenovirus; In vivo; Biology; Mutant; In vitro; Cancer research; Cancer cell; Cancer; Growth inhibition; Virology; Tumor cells; Gene; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007235356,0.0005380207,0.0003246017,0.0002850748,0.0001956243,0.0004217303,0.0003037503,0.0003831743,0.0005747369],"category_scores_gemma":[0.0004695321,0.0001673775,0.0002682756,0.0001705882,0.0003306655,0.0003031525,0.0001357931,0.0005048602,0.0001703142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003568635,"about_ca_system_score_gemma":0.0003237003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006065371,"about_ca_topic_score_gemma":0.0005974282,"domain_scores_codex":[0.9997333,0.00007621942,0.00004246876,0.00003685396,0.00006083207,0.00005044358],"domain_scores_gemma":[0.9997008,0.000120658,0.00005662396,0.00003812027,0.00003784577,0.00004598243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002126285,0.0001358776,0.0003078669,0.00006406831,0.000008528475,0.00003922133,0.00002066466,0.0004464904,0.9955259,0.0003365869,0.00003101663,0.002871034],"study_design_scores_gemma":[0.00003037475,0.001298986,0.0004659438,0.00000533617,0.00002256317,0.000155309,0.00001008293,0.0007972446,0.9954864,0.00003000519,0.001692377,0.000005388157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899094,0.002623091,0.00608719,0.00006966635,0.00002975167,0.0001695682,0.000248032,0.00005043796,0.0008129375],"genre_scores_gemma":[0.9825523,0.00277925,0.01236602,0.0000279466,0.000009809702,0.0001189875,0.0006132594,0.00002864668,0.00150378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007235356,"threshold_uncertainty_score":0.003826499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06880618687229809,"score_gpt":0.4018169728584107,"score_spread":0.3330107859861126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}