{"id":"W2003855355","doi":"10.1016/j.bmcl.2011.06.006","title":"Evaluation of FKBP and DHFR based destabilizing domains in Saccharomyces cerevisiae","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"FKBP; Saccharomyces cerevisiae; Chemistry; Yeast; Mutant; In vivo; In vitro; Cell biology; Directed evolution; Biochemistry; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009894756,0.0001716271,0.0001773669,0.00002995772,0.00002779674,0.000005426827,0.0001914367,0.0001164204,0.0002291183],"category_scores_gemma":[0.0004656891,0.0001697059,0.0000500766,0.0001125217,0.000207082,0.000004541562,0.0000550574,0.00009870945,0.000001375785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005473893,"about_ca_system_score_gemma":0.00025644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003069445,"about_ca_topic_score_gemma":0.000005668446,"domain_scores_codex":[0.9986054,0.0001011262,0.000291133,0.0003708529,0.000420379,0.0002111202],"domain_scores_gemma":[0.999289,0.00002449915,0.0001350245,0.000336037,0.0001053499,0.0001100538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006320192,0.00006097294,0.01857448,0.0001178539,0.00002703677,0.00000762656,0.0001154787,0.000004445639,0.9798813,0.000001044754,0.0001308053,0.00101575],"study_design_scores_gemma":[0.001361606,0.00004130725,0.01215678,0.0001260754,0.000134806,0.00001379614,0.0001988513,0.00008959388,0.9856202,0.00002421704,0.00006152775,0.0001712111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975519,0.001493092,0.0001999358,0.000186498,0.000050734,0.0001640619,0.00001002559,0.00001055784,0.0003332499],"genre_scores_gemma":[0.9989205,0.00002092279,0.0005531803,0.0003041688,0.0001224078,0.00001544715,0.00003842767,0.00002138839,0.000003578137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006417697,"threshold_uncertainty_score":0.6920404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04110595737420808,"score_gpt":0.2577830116315878,"score_spread":0.2166770542573797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}