{"id":"W2003885794","doi":"10.1158/0008-5472.can-12-1339-t","title":"Concomitant Targeting of Tumor Cells and Induction of T-cell Response Synergizes to Effectively Inhibit Trastuzumab-Resistant Breast Cancer","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; University of Pennsylvania","keywords":"Trastuzumab; Cancer research; Tumor microenvironment; Cytotoxic T cell; CD8; PTEN; Medicine; PI3K/AKT/mTOR pathway; Breast cancer; T cell; Protein kinase B; Mammary tumor; Antibody; Cancer; Immunology; Antigen; Immune system; Biology; Internal medicine; Signal transduction; In vitro; Cell biology; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001379845,0.0003323282,0.0003638715,0.0002193216,0.00007410266,0.0002124407,0.000152511,0.0001629951,0.0007955021],"category_scores_gemma":[0.00009263766,0.0001010649,0.0001611861,0.0001511131,0.0001323328,0.0001317459,0.0001801176,0.0004422647,0.0002223029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001614553,"about_ca_system_score_gemma":0.0002039129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000182157,"about_ca_topic_score_gemma":0.0006486981,"domain_scores_codex":[0.9998466,0.00003670212,0.00001157057,0.00002385889,0.00003481807,0.0000464292],"domain_scores_gemma":[0.9999557,0.000007971104,0.00001045805,0.000008175462,0.000003837541,0.00001394441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003794277,0.0002667023,0.0002821735,0.000051373,0.00001668636,0.00005899174,0.00001199661,0.0004480359,0.988416,0.0001439539,0.0001312984,0.00979335],"study_design_scores_gemma":[0.0001460212,0.002342054,0.002431172,0.000004603583,0.00005103393,0.0004694058,0.00001022862,0.001943313,0.9884022,0.00005628008,0.00413982,0.000003983715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924763,0.002141835,0.002513319,0.0000835343,0.00003316835,0.00007416224,0.00008210154,0.0001074192,0.002488174],"genre_scores_gemma":[0.9963787,0.0007737343,0.001635421,0.00003582282,0.00001875592,0.00003658183,0.00009413885,0.00001000818,0.001016874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007955021,"threshold_uncertainty_score":0.002661228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05514960438187381,"score_gpt":0.3974450834618022,"score_spread":0.3422954790799284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}