{"id":"W2003891352","doi":"10.1007/s10875-014-9992-8","title":"Very Early Onset Inflammatory Bowel Disease Associated with Aberrant Trafficking of IL-10R1 and Cure by T Cell Replete Haploidentical Bone Marrow Transplantation","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Immunology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children; SickKids Foundation","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Biology; Transplantation; Sanger sequencing; Hematopoietic stem cell transplantation; Mutation; Inflammatory bowel disease; Immunology; Molecular biology; Stem cell; Genetics; Gene; Disease; Medicine; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001508357,0.0001923933,0.0004653935,0.00007161553,0.00006684289,0.00002025467,0.0001995588,0.0003311454,0.00001160006],"category_scores_gemma":[0.001025851,0.000163398,0.0002468216,0.00004277921,0.0004694848,0.0000239917,0.00003942708,0.0004934401,0.000002350256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001217269,"about_ca_system_score_gemma":0.0002216781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000205477,"about_ca_topic_score_gemma":0.00001180939,"domain_scores_codex":[0.9971684,0.0007927538,0.001276537,0.0002622042,0.0002438284,0.0002562717],"domain_scores_gemma":[0.9978879,0.0002779956,0.001053154,0.0002715708,0.000277535,0.0002318117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02152355,0.0009853394,0.8011793,0.0002204948,0.001038265,0.0008954262,0.0002212638,0.0001151892,0.1703975,0.00004842568,0.001839336,0.001535811],"study_design_scores_gemma":[0.005292662,0.001436267,0.9871036,0.0001585906,0.0004439523,0.00007604634,0.00003446517,0.000124412,0.004175831,0.00006771777,0.0008596338,0.0002268551],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979953,0.0009543403,0.0004199012,0.0001788982,0.0002389279,0.000119472,0.00005688381,0.000007757278,0.00002848533],"genre_scores_gemma":[0.9983597,0.001066897,0.0001133952,0.0001616318,0.0001326605,0.000003192034,0.0000547608,0.000028678,0.00007908516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1859242,"threshold_uncertainty_score":0.6663178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008769630970649589,"score_gpt":0.2562922633141946,"score_spread":0.247522632343545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}