{"id":"W2003893081","doi":"10.1182/blood-2007-12-129080","title":"Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":255,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC; Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance","keywords":"Chemokine; Macrophage inflammatory protein; CXCL2; Chemistry; CXCL1; Inflammation; CXCL14; CXC chemokine receptors; Macrophage; Matrix metalloproteinase; Interleukin 8; Immunology; Monocyte; Molecular biology; Chemotaxis; Lipopolysaccharide; Biology; Receptor; CXCL10; Biochemistry; Chemokine receptor; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002419487,0.0005427372,0.0003586814,0.0001930784,0.0001265333,0.0003510363,0.0001990627,0.0004110838,0.002003188],"category_scores_gemma":[0.0001356175,0.0001489864,0.00039413,0.000104009,0.000288618,0.000215678,0.0001848753,0.0008089306,0.0008096452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002210466,"about_ca_system_score_gemma":0.0001832369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003650269,"about_ca_topic_score_gemma":0.0006487546,"domain_scores_codex":[0.9997305,0.00004369457,0.00003197159,0.00005125189,0.00005537493,0.00008717192],"domain_scores_gemma":[0.9998387,0.00001487152,0.00005647197,0.00002056996,0.00002401139,0.00004534419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000161542,0.00003085266,0.0001756384,0.00003840591,0.000003476642,0.00003225529,0.000007839927,0.00001592003,0.99862,0.00004009121,0.0000348561,0.0008391626],"study_design_scores_gemma":[0.00002030505,0.000308494,0.001996909,0.000005472848,0.00001099141,0.0002483386,0.00001302683,0.0002685244,0.9957384,0.00002075137,0.001366326,0.000002430944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894413,0.002535772,0.006052873,0.0002765366,0.00005535165,0.00005327422,0.0006587397,0.000191099,0.0007350444],"genre_scores_gemma":[0.9860572,0.001152951,0.006294205,0.00009207932,0.00002872757,0.00008547743,0.0007413158,0.00003261416,0.005515537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002003188,"threshold_uncertainty_score":0.00670135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003902297176910423,"score_gpt":0.1710623180851651,"score_spread":0.1671600209082547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}