{"id":"W2003893081","doi":"10.1182/blood-2007-12-129080","title":"Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":255,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC; Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance","keywords":"Chemokine; Macrophage inflammatory protein; CXCL2; Chemistry; CXCL1; Inflammation; CXCL14; CXC chemokine receptors; Macrophage; Matrix metalloproteinase; Interleukin 8; Immunology; Monocyte; Molecular biology; Chemotaxis; Lipopolysaccharide; Biology; Receptor; CXCL10; Biochemistry; Chemokine receptor; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001204781,0.0002337929,0.0002419195,0.00005684181,0.0001961703,0.00004196095,0.0001315345,0.0001546093,0.00001129457],"category_scores_gemma":[0.00004032396,0.0001860467,0.00005514712,0.00008937928,0.0002685663,0.0000206672,0.00030732,0.0001354619,6.910203e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006824754,"about_ca_system_score_gemma":0.00003467623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001047483,"about_ca_topic_score_gemma":0.00002057161,"domain_scores_codex":[0.9988721,0.00007227269,0.0002716415,0.0004025887,0.0001242437,0.0002571304],"domain_scores_gemma":[0.9994993,0.0000122545,0.0001343261,0.0002387527,0.0000335827,0.00008176997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007929535,0.000134635,0.004880833,0.00003468679,0.00004258952,0.00004047317,0.0001349555,0.000002081845,0.9930922,0.00002127644,0.00002673441,0.001510191],"study_design_scores_gemma":[0.001890202,0.0002024748,0.008681814,0.00003195246,0.00003624841,0.000354137,0.0001912193,0.00006237003,0.9877896,0.0001053664,0.0004501075,0.0002045009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873074,0.0122433,0.000004743512,0.0000387582,0.00004933352,0.0002194174,0.00004717822,0.000008179493,0.0000817451],"genre_scores_gemma":[0.9970421,0.002104968,0.0004852984,0.0000640258,0.0001396739,0.0000157439,0.0000229485,0.00003110906,0.00009408357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01013833,"threshold_uncertainty_score":0.7586765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003902297176910423,"score_gpt":0.1710623180851651,"score_spread":0.1671600209082547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}