{"id":"W2003895629","doi":"10.1074/jbc.m112.380949","title":"Negative Regulation of Human Growth Hormone Gene Expression by Insulin Is Dependent on Hypoxia-inducible Factor Binding in Primary Non-tumor Pituitary Cells","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Endocrinology; Hypoxia (environmental); Internal medicine; Gene expression; Hormone; Chemistry; Hypoxia-inducible factors; Growth hormone; Tumor cells; Insulin; Gene; Biology; Cell biology; Cancer research; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001412809,0.0002344861,0.0002348416,0.0001293306,0.0001106898,0.0002310639,0.0001485324,0.00009299781,0.001675054],"category_scores_gemma":[0.0001008965,0.0001637239,0.0001934663,0.0001138309,0.0001938265,0.00008232835,0.0001559086,0.0003232367,0.0004957724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002467828,"about_ca_system_score_gemma":0.0001592298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009166674,"about_ca_topic_score_gemma":0.001451645,"domain_scores_codex":[0.9998061,0.00002545218,0.00001575172,0.00004856784,0.00007391049,0.00003032167],"domain_scores_gemma":[0.999868,0.00004296541,0.00002840631,0.00001933211,0.00001495806,0.00002632747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004962339,0.000006666476,0.0000470976,0.000008017215,0.000001044577,0.00001222976,0.000004513707,0.000004173004,0.9996203,0.0000117722,0.00001524622,0.0002192918],"study_design_scores_gemma":[0.00001593568,0.0001757024,0.007635088,0.000003509562,0.000006881475,0.0001480679,0.00001337937,0.0003792876,0.9894184,0.00002026623,0.00218101,0.000002552375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878302,0.00242511,0.005498435,0.0001346102,0.00007391932,0.00004935414,0.0009718809,0.0001750881,0.002841238],"genre_scores_gemma":[0.9831756,0.001751746,0.005762033,0.0001099829,0.00003390338,0.00009204801,0.002941463,0.00007962506,0.006053617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001675054,"threshold_uncertainty_score":0.005603552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0176379672278333,"score_gpt":0.2466082949688639,"score_spread":0.2289703277410305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}