{"id":"W2003910307","doi":"10.1007/s11248-010-9369-6","title":"Production of mouse chimeras by injection of embryonic stem cells into the perivitelline space of one-cell stage embryos","year":2010,"lang":"en","type":"article","venue":"Transgenic Research","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Agence Nationale pour la Gestion des Déchets Radioactifs","keywords":"Perivitelline space; Electrofusion; Biology; Embryo; Embryonic stem cell; Chimera (genetics); Blastocyst; Zona pellucida; Cell biology; Blastomere; Stem cell; Genetics; Andrology; Embryogenesis; Immunology; Molecular biology; Oocyte; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001052531,0.0008010516,0.0007956647,0.001304774,0.000460287,0.0007092239,0.001099742,0.001133009,0.004596752],"category_scores_gemma":[0.0004721428,0.0006763805,0.0007713443,0.0004091306,0.0006697454,0.0006806263,0.0007758851,0.002212482,0.001858836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005128226,"about_ca_system_score_gemma":0.0004537401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005841344,"about_ca_topic_score_gemma":0.0007488971,"domain_scores_codex":[0.9994313,0.0000681969,0.00008215484,0.000157556,0.0001592563,0.0001014105],"domain_scores_gemma":[0.9992059,0.0001338098,0.0002152543,0.000171151,0.0000564751,0.0002175282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001540497,0.00004716776,0.0001368942,0.00004651343,0.00001746083,0.0001417436,0.00005612511,0.00009529365,0.9963043,0.001331081,0.00014743,0.001522022],"study_design_scores_gemma":[0.00006579838,0.0001206234,0.000777161,0.00001953155,0.0000436859,0.0006027284,0.0000302174,0.0007179189,0.9898566,0.0001982843,0.007555857,0.00001157986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8809673,0.002133448,0.09412777,0.0009071195,0.0007739472,0.0009935035,0.006517982,0.002377512,0.01120153],"genre_scores_gemma":[0.880579,0.003245489,0.06650694,0.0003265795,0.0000838733,0.001030013,0.006020767,0.001623152,0.04058424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004596752,"threshold_uncertainty_score":0.01537764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02719205326628089,"score_gpt":0.3073683908172104,"score_spread":0.2801763375509295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}