{"id":"W2003910307","doi":"10.1007/s11248-010-9369-6","title":"Production of mouse chimeras by injection of embryonic stem cells into the perivitelline space of one-cell stage embryos","year":2010,"lang":"en","type":"article","venue":"Transgenic Research","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Agence Nationale pour la Gestion des Déchets Radioactifs","keywords":"Perivitelline space; Electrofusion; Biology; Embryo; Embryonic stem cell; Chimera (genetics); Blastocyst; Zona pellucida; Cell biology; Blastomere; Stem cell; Genetics; Andrology; Embryogenesis; Immunology; Molecular biology; Oocyte; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002255776,0.0001632176,0.0002699449,0.0001838213,0.0001160341,0.00001350896,0.000644838,0.0002305949,0.00008030707],"category_scores_gemma":[0.0000532685,0.0001321464,0.0001605331,0.000512524,0.0006805248,0.00001109332,0.0001232582,0.0006759071,0.00001121243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001992598,"about_ca_system_score_gemma":0.0002829879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004626824,"about_ca_topic_score_gemma":0.000275229,"domain_scores_codex":[0.9972385,0.0004956051,0.0004368863,0.0004297402,0.0009627558,0.0004365039],"domain_scores_gemma":[0.9980668,0.00007828796,0.0001497491,0.0009935648,0.0006095174,0.0001020348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004215113,0.0004603707,0.000293386,0.000523018,0.00007511611,2.287881e-7,0.0005747582,0.0002379796,0.995641,0.0000223503,0.0008287117,0.0009215738],"study_design_scores_gemma":[0.0005101239,0.0008374535,0.0001229032,0.00001598185,0.00001423629,0.000001552201,0.0005223149,0.00009957371,0.9951798,0.000007394552,0.002579293,0.0001093761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970286,0.0009073891,0.0003198066,0.000330007,0.0001263984,0.0008806695,0.00004407098,0.000006563572,0.0003565187],"genre_scores_gemma":[0.9643927,0.001585571,0.0001548831,0.000002641357,0.00007821872,0.00003503889,0.00003468548,0.00003884059,0.03367738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03332086,"threshold_uncertainty_score":0.5388775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02719205326628089,"score_gpt":0.3073683908172104,"score_spread":0.2801763375509295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}