{"id":"W2003926050","doi":"10.1172/jci16409","title":"Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood","year":2003,"lang":"en","type":"letter","venue":"Journal of Clinical Investigation","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":211,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Simon Fraser University; University of Alberta; BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Fondation pour la Recherche Médicale; Children's Hospital Foundation; Michael Smith Health Research BC; Canadian Diabetes Association","keywords":"Immunology; Autoimmune diabetes; Autoimmunity; Peripheral blood; Type 1 diabetes; NOD mice; Major histocompatibility complex; Nod; Diabetes mellitus; Medicine; Avidity; Autoimmune disease; Peripheral; Antigen; Immune system; Endocrinology; Internal medicine; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001224311,0.0005829658,0.0004588993,0.0004761762,0.0002975091,0.0005668249,0.0003761499,0.002179389,0.001300493],"category_scores_gemma":[0.003749136,0.0002528736,0.0001946564,0.0001976758,0.0004947218,0.0003947028,0.0001892011,0.001839099,0.001022861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004727359,"about_ca_system_score_gemma":0.0001162111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001578822,"about_ca_topic_score_gemma":0.0001790727,"domain_scores_codex":[0.9989921,0.0004563369,0.0001101173,0.0001306569,0.0002343279,0.00007629297],"domain_scores_gemma":[0.9978771,0.00131551,0.000185028,0.0002700915,0.00017318,0.0001790744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01405657,0.002384227,0.1466462,0.0007896129,0.0002133445,0.1354846,0.0006081178,0.001862989,0.4533794,0.008617407,0.05089679,0.1850608],"study_design_scores_gemma":[0.003284594,0.008321233,0.1790408,0.0005546496,0.0002842116,0.3705668,0.0003689775,0.04724433,0.2812266,0.01896753,0.0899399,0.000200435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9096723,0.004521558,0.01538725,0.03318214,0.002983302,0.0002905825,0.0007824491,0.001005374,0.03217508],"genre_scores_gemma":[0.9750759,0.002214607,0.00550104,0.006745719,0.002021661,0.0001533483,0.0004322907,0.00008625652,0.007769275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002179389,"threshold_uncertainty_score":0.006474853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02212449415568732,"score_gpt":0.2718752414027618,"score_spread":0.2497507472470744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}