{"id":"W2003946870","doi":"10.1083/jcb.200508130","title":"Osteoblast differentiation and skeletal development are regulated by Mdm2–p53 signaling","year":2006,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":262,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute","keywords":"Biology; Osteoblast; RUNX2; Mdm2; Cell biology; Conditional gene knockout; Progenitor cell; Cre recombinase; Cellular differentiation; Stem cell; Endocrinology; Transgene; Genetically modified mouse; Genetics; Cell culture; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001220276,0.000269958,0.0001720087,0.000317402,0.0002319744,0.0003488713,0.0001200415,0.0002965734,0.001545987],"category_scores_gemma":[0.0001722735,0.0002510805,0.0001683244,0.0001395319,0.0002651575,0.0001633933,0.0003380548,0.0003375235,0.0004144372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001785392,"about_ca_system_score_gemma":0.000173158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000316946,"about_ca_topic_score_gemma":0.001003042,"domain_scores_codex":[0.9998302,0.00002257685,0.00001239348,0.00002436351,0.00006119093,0.00004930259],"domain_scores_gemma":[0.9998993,0.00001361137,0.00004048242,0.000007341434,0.000009368593,0.00002982627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001925293,0.00002503109,0.001347831,0.00002285754,0.000003726022,0.000251335,0.0000138069,0.00004747331,0.9943591,0.000286464,0.00007733772,0.003372697],"study_design_scores_gemma":[0.00005470878,0.0003627696,0.06979787,0.00001430464,0.00002296277,0.001980309,0.00009725179,0.001136118,0.91859,0.0004527343,0.007481759,0.000009157859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912657,0.003430355,0.001947982,0.0001252069,0.00001932755,0.00001438082,0.0002883071,0.00007612468,0.002832439],"genre_scores_gemma":[0.9934341,0.001671562,0.00118431,0.00003423071,0.00001065055,0.00002369071,0.0003246731,0.00001183748,0.003304985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001545987,"threshold_uncertainty_score":0.005171895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005693595527498253,"score_gpt":0.2035119910206819,"score_spread":0.1978183954931836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}