{"id":"W2003955696","doi":"10.1038/sj.gt.3302036","title":"Molecular basis of the inflammatory response to adenovirus vectors","year":2003,"lang":"en","type":"review","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":427,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Libin Cardiovascular Institute of Alberta","funders":"","keywords":"Biology; Adenoviridae; Innate immune system; Viral vector; Chemokine; Genetic enhancement; Transduction (biophysics); Acquired immune system; Vectors in gene therapy; Cell biology; Gene delivery; Proinflammatory cytokine; Immune system; Virology; Inflammation; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006140004,0.001023142,0.00127778,0.001590293,0.0003088662,0.001302984,0.00113821,0.001391272,0.001420578],"category_scores_gemma":[0.000368418,0.0004159384,0.0003537231,0.001231657,0.001148394,0.001084152,0.0004258722,0.002728521,0.001563668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001507988,"about_ca_system_score_gemma":0.001160732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001265937,"about_ca_topic_score_gemma":0.001252658,"domain_scores_codex":[0.999836,0.00002481999,0.00002050177,0.00003146291,0.00006583174,0.0000214621],"domain_scores_gemma":[0.9998248,0.00008003793,0.00001712303,0.000009364787,0.00005490009,0.00001371203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004114077,0.0002881677,0.0003933145,0.01319484,0.00008871127,0.001509668,0.0001588828,0.002246117,0.07763842,0.04145105,0.02823843,0.8343809],"study_design_scores_gemma":[0.00005615916,0.0001337448,0.0007387176,0.001103651,0.00007143701,0.00242878,0.00007992215,0.0003422681,0.02372086,0.0112338,0.9600525,0.00003809963],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004138884,0.9948341,0.001620746,0.0004412827,0.0004274453,0.00001122081,0.00002776849,0.00001890754,0.002204694],"genre_scores_gemma":[0.002367152,0.9948117,0.0008450983,0.0001981829,0.000215573,0.00001883496,0.00004431308,0.000002971593,0.001496259],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001590293,"threshold_uncertainty_score":0.01094121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0327122993411928,"score_gpt":0.3356475460909968,"score_spread":0.302935246749804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}