{"id":"W2004001628","doi":"10.1002/ijc.23351","title":"Prohibitin silencing reverses stabilization of mitochondrial integrity and chemoresistance in ovarian cancer cells by increasing their sensitivity to apoptosis","year":2008,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; Canadian Institutes of Health Research; U.S. Department of Defense; Fogarty International Center; National Institutes of Health; National Center for Research Resources","keywords":"Prohibitin; Biology; Ovarian cancer; Gene silencing; Cancer research; Apoptosis; Cell cycle; Cancer cell; Cancer; Cell growth; Molecular biology; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002937246,0.00008153588,0.0001508697,0.00008643723,0.00002663131,0.00001382948,0.0001080114,0.00005508396,0.00001375578],"category_scores_gemma":[0.0002611363,0.00007140786,0.00004603678,0.00007787235,0.00005562017,0.00001938669,0.00005279358,0.0001450828,1.128915e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001078662,"about_ca_system_score_gemma":0.000251025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001950945,"about_ca_topic_score_gemma":0.001205127,"domain_scores_codex":[0.9991047,0.00009441905,0.000280889,0.000135118,0.0002680209,0.000116821],"domain_scores_gemma":[0.9991389,0.00004298301,0.0001930299,0.00006075947,0.0004951738,0.00006913806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008328892,0.00003610147,0.02033542,0.00001275619,0.00005412349,0.000005778769,0.0001914181,0.0003055572,0.9760541,0.000003695067,0.0007530289,0.001415096],"study_design_scores_gemma":[0.0006463802,0.0000615558,0.01138526,0.0002083627,0.000005171279,0.00001913189,0.0001158674,0.0001048934,0.9870164,0.00001105005,0.0003534003,0.00007249198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996339,0.0007183647,0.002024546,0.0005129089,0.0002264456,0.00009162461,0.00005995907,9.900519e-7,0.00002613393],"genre_scores_gemma":[0.9971665,0.001479895,0.0008640286,0.0001211683,0.0002979712,0.000005603712,0.000004654748,0.000008104692,0.00005204281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01096229,"threshold_uncertainty_score":0.2949259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0131496080367054,"score_gpt":0.2919876239258506,"score_spread":0.2788380158891452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}