{"id":"W2004003656","doi":"10.1128/aac.04652-14","title":"Safety and Pharmacokinetics of Solithromycin in Subjects with Hepatic Impairment","year":2015,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celerion (Canada)","funders":"","keywords":"Medicine; Pharmacokinetics; Adverse effect; Internal medicine; Cohort; Diarrhea; Population; Gastroenterology; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004711883,0.0002501906,0.0005323138,0.0001333342,0.0002345427,0.0002336619,0.00007755622,0.0002854706,0.0006598023],"category_scores_gemma":[0.001046647,0.0001478072,0.0002089688,0.0001410073,0.0002304751,0.0002181428,0.000133745,0.0003034811,0.0001388371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002089351,"about_ca_system_score_gemma":0.0002449501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006718926,"about_ca_topic_score_gemma":0.001076347,"domain_scores_codex":[0.999754,0.000114988,0.00002244161,0.00003401461,0.00004801104,0.0000265785],"domain_scores_gemma":[0.9994789,0.0001449661,0.000179021,0.00003891438,0.00006647298,0.00009165017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1044326,0.004840755,0.5696824,0.0004946916,0.0004695713,0.001826456,0.001157057,0.001095612,0.1543177,0.0001068835,0.0009002464,0.160676],"study_design_scores_gemma":[0.003198477,0.1153613,0.8626289,0.00004198879,0.000313296,0.001606963,0.0003661469,0.001633905,0.01269683,0.00008841994,0.002039411,0.00002435677],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991083,0.0003879109,0.00009521853,0.00002559455,0.00000339262,0.00002203142,0.00002979981,0.000006977157,0.000320879],"genre_scores_gemma":[0.9994556,0.000140363,0.00008511983,0.00004877813,0.00001554753,0.00001387802,0.0000514718,0.000001706822,0.000187646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006718926,"threshold_uncertainty_score":0.002491891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0156777975733485,"score_gpt":0.2750619069029889,"score_spread":0.2593841093296403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}