{"id":"W2004012709","doi":"10.1042/bj20031546","title":"Cell viability and secretion of active proteins in Schizosaccharomyces pombe do not require the chaperone function of calnexin","year":2004,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Medical Research Council Canada; Université de Montréal","keywords":"Calnexin; Schizosaccharomyces pombe; Chaperone (clinical); Endoplasmic reticulum; Secretion; Protein folding; Secretory protein; Cell biology; Biology; Secretory pathway; Unfolded protein response; Schizosaccharomyces; Mutant; Endoplasmic-reticulum-associated protein degradation; Yeast; Biochemistry; Saccharomyces cerevisiae; Calreticulin; Golgi apparatus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001316069,0.0004937563,0.0003431209,0.0002098763,0.000252538,0.0005535532,0.00022756,0.0003180987,0.0009278401],"category_scores_gemma":[0.0002465122,0.0001854252,0.0002657996,0.0002181722,0.000276243,0.0002892999,0.0003221799,0.0005095138,0.0005120217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004086891,"about_ca_system_score_gemma":0.000294457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001412555,"about_ca_topic_score_gemma":0.001601642,"domain_scores_codex":[0.9998398,0.00002488895,0.00002235521,0.00003265453,0.00005656787,0.00002365311],"domain_scores_gemma":[0.9997687,0.00004841541,0.00004245002,0.00004887202,0.00002480813,0.00006676778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009831196,0.00002135831,0.0001492612,0.0000199201,0.000003343175,0.0000582703,0.00001827347,0.00005847839,0.9989303,0.0001130401,0.00002010097,0.0005092736],"study_design_scores_gemma":[0.00002303824,0.0002353646,0.006072865,0.000006701978,0.00001029461,0.000285785,0.00005251463,0.001091605,0.9896825,0.0001393493,0.002390992,0.000009096618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912143,0.001626811,0.003737638,0.0001434504,0.00003704858,0.00003563134,0.001338006,0.0001036086,0.001763434],"genre_scores_gemma":[0.9915127,0.0004925183,0.002515213,0.00003470053,0.000005020241,0.00002909451,0.002738802,0.00005061949,0.002621333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001412555,"threshold_uncertainty_score":0.003103912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006497518783146312,"score_gpt":0.2248174742582526,"score_spread":0.2183199554751063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}