{"id":"W2004012709","doi":"10.1042/bj20031546","title":"Cell viability and secretion of active proteins in Schizosaccharomyces pombe do not require the chaperone function of calnexin","year":2004,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Medical Research Council Canada; Université de Montréal","keywords":"Calnexin; Schizosaccharomyces pombe; Chaperone (clinical); Endoplasmic reticulum; Secretion; Protein folding; Secretory protein; Cell biology; Biology; Secretory pathway; Unfolded protein response; Schizosaccharomyces; Mutant; Endoplasmic-reticulum-associated protein degradation; Yeast; Biochemistry; Saccharomyces cerevisiae; Calreticulin; Golgi apparatus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001655707,0.00009821109,0.000128868,0.00002264641,0.00003953878,0.0000102799,0.00009880479,0.0001136239,0.00001394974],"category_scores_gemma":[0.00007509426,0.00006809428,0.00007177154,0.00006270851,0.0001932885,0.000009213212,0.0000606648,0.0001463778,3.354752e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000192766,"about_ca_system_score_gemma":0.00008589897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002674549,"about_ca_topic_score_gemma":0.000002380528,"domain_scores_codex":[0.999239,0.00005004441,0.0002579859,0.0001738665,0.0001505317,0.0001285458],"domain_scores_gemma":[0.9995146,0.00001110486,0.0001659247,0.0001482302,0.00007916069,0.0000810014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007281831,0.0001578051,0.001377579,0.00006141911,0.00001662985,0.000001648179,0.00006421826,0.00001980574,0.9967159,0.0001041349,0.00001393017,0.0007387697],"study_design_scores_gemma":[0.001188666,0.0003005731,0.01555558,0.00007306432,0.00002008088,0.00001793822,0.0002699143,0.000008226714,0.9817443,0.0006922866,0.00005006197,0.0000792381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980927,0.001006709,0.0003664886,0.0002025682,0.00003868546,0.0001571672,0.00002752147,0.000001718638,0.0001064706],"genre_scores_gemma":[0.9993952,0.0002477699,0.0002295206,0.00002062736,0.00007274959,0.000008104378,0.00001160937,0.000006417373,0.000007991091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01497151,"threshold_uncertainty_score":0.2776804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006497518783146312,"score_gpt":0.2248174742582526,"score_spread":0.2183199554751063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}