{"id":"W2004023311","doi":"10.1016/j.eururo.2014.08.006","title":"Combination AZD5363 with Enzalutamide Significantly Delays Enzalutamide-resistant Prostate Cancer in Preclinical Models","year":2014,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Enzalutamide; LNCaP; Medicine; Prostate cancer; Protein kinase B; Cancer research; PI3K/AKT/mTOR pathway; Androgen receptor; Apoptosis; Cell growth; Internal medicine; Pharmacology; Cancer; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001031215,0.0002496726,0.000432755,0.0002250835,0.00008445459,0.00002562181,0.0001774971,0.00008735117,0.00009788002],"category_scores_gemma":[0.0001374975,0.0001806415,0.00006496863,0.0002884496,0.000286334,0.0001173273,0.00008600404,0.0005163972,0.00009527807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001436479,"about_ca_system_score_gemma":0.0002063483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001228683,"about_ca_topic_score_gemma":0.0002155875,"domain_scores_codex":[0.9971949,0.0007798861,0.0004721905,0.0006142903,0.0003373781,0.0006012994],"domain_scores_gemma":[0.9988087,0.0002631588,0.0001328522,0.000409714,0.0001639179,0.0002216535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1042881,0.007403569,0.4741187,0.001234854,0.001715445,0.008374775,0.01313174,0.04044084,0.1216857,0.02158332,0.005992488,0.2000304],"study_design_scores_gemma":[0.06041945,0.02240343,0.7895057,0.0006356693,0.0007849396,0.0002556037,0.0004013485,0.07455176,0.007173741,0.007225768,0.03493761,0.001704939],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650002,0.001049016,0.0005680789,0.004486362,0.0001390355,0.001003867,0.00003040816,0.0001218438,0.02760118],"genre_scores_gemma":[0.9963087,0.0004611977,0.0002103158,0.0009180039,0.0001284068,0.00008557858,0.00005674823,0.00007919256,0.001751804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.315387,"threshold_uncertainty_score":0.7366345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03715134515925831,"score_gpt":0.3174256758623464,"score_spread":0.2802743307030881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}