{"id":"W2004027999","doi":"10.1371/journal.pgen.1004423","title":"Phenotypic Dissection of Bone Mineral Density Reveals Skeletal Site Specificity and Facilitates the Identification of Novel Loci in the Genetic Regulation of Bone Mass Attainment","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":168,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill University","funders":"National Center for Research Resources; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Education, Audiovisual and Culture Executive Agency; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; U.S. Public Health Service; National Institutes of Health; University of Bristol; Erasmus Medisch Centrum; European Commission; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Novo Nordisk Fonden; School of Medicine, Boston University; ZonMw; Erasmus Universiteit Rotterdam","keywords":"Bone mineral; Heritability; Biology; Longitudinal study; Bone density; Appendicular skeleton; Genetic correlation; Internal medicine; Genetics; Endocrinology; Genetic variation; Anatomy; Medicine; Osteoporosis; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001214019,0.0003744979,0.0004707239,0.0009832418,0.00016083,0.0005130561,0.0002976995,0.000292111,0.0008922062],"category_scores_gemma":[0.001982986,0.0002486311,0.0005338943,0.001275643,0.0003541482,0.0001548772,0.0005777613,0.0003627555,0.0001209676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001282998,"about_ca_system_score_gemma":0.0001730761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002889757,"about_ca_topic_score_gemma":0.005339585,"domain_scores_codex":[0.9991063,0.0003839671,0.00005600326,0.0002873475,0.0001196109,0.00004680198],"domain_scores_gemma":[0.9991488,0.0003831389,0.0002373663,0.0001689625,0.00003378225,0.00002788755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004839818,0.00006670186,0.8564306,0.0001649834,0.001835073,0.0006283069,0.0002677871,0.00184325,0.1041431,0.0008855193,0.0001846863,0.03306597],"study_design_scores_gemma":[0.00001123982,0.00004936514,0.9959698,0.000009993829,0.0002550752,0.0002338038,0.00003535674,0.001227085,0.001621427,0.0003283885,0.0002532189,0.000005145668],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896984,0.001245694,0.007433948,0.00006487746,0.000004885669,0.00001016218,0.0006540901,0.00004537438,0.0008425742],"genre_scores_gemma":[0.9973677,0.0003430889,0.001868453,0.00002469873,0.000004816066,0.000007447782,0.0002323438,0.00000762366,0.0001438494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002889757,"threshold_uncertainty_score":0.006420374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01535249757476617,"score_gpt":0.2376400829137345,"score_spread":0.2222875853389684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}