{"id":"W2004042055","doi":"10.1016/j.ygyno.2013.08.003","title":"MMR deficiency is common in high-grade endometrioid carcinomas and is associated with an unfavorable outcome","year":2013,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto; Calgary Laboratory Services; University of Calgary","funders":"Health Research Board; Calgary Laboratory Services; Memorial Sloan-Kettering Cancer Center","keywords":"Medicine; PTEN; MSH2; MLH1; Subtyping; Endometrial cancer; Oncology; Univariate analysis; Internal medicine; ARID1A; Cancer; DNA mismatch repair; Multivariate analysis; Mutation; Biology; Apoptosis; Gene; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004240187,0.0002923624,0.0004148489,0.001342361,0.0002775254,0.0004500776,0.0002935427,0.000428576,0.001589699],"category_scores_gemma":[0.001947914,0.000163613,0.0002896026,0.001217881,0.0003409984,0.0002232439,0.0003240368,0.0003470876,0.0002900472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001962436,"about_ca_system_score_gemma":0.0002254166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004912365,"about_ca_topic_score_gemma":0.0004011023,"domain_scores_codex":[0.9997037,0.00007704156,0.00004489139,0.00005817189,0.00006410342,0.00005203932],"domain_scores_gemma":[0.9980239,0.00043399,0.001089531,0.0001314929,0.00012141,0.0001997705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001098262,0.00004172486,0.9521161,0.00009769747,0.0001324356,0.004931149,0.00006921619,0.00007635451,0.02908164,0.0001494451,0.0002102241,0.01199589],"study_design_scores_gemma":[0.00001662894,0.0002084765,0.9660755,0.0000238157,0.0001286453,0.02349734,0.0001941922,0.0002603401,0.007632135,0.0002555302,0.001696349,0.0000110263],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941718,0.003814491,0.0004590939,0.0001473341,0.00002001249,0.000008144742,0.0004797472,0.00002897324,0.0008703444],"genre_scores_gemma":[0.9985832,0.0006516997,0.0002268605,0.00002906802,0.00001687423,0.000003495446,0.000272161,0.000003810895,0.0002128749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001589699,"threshold_uncertainty_score":0.005318046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02213431047915189,"score_gpt":0.2848414856488556,"score_spread":0.2627071751697037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}