{"id":"W2004042055","doi":"10.1016/j.ygyno.2013.08.003","title":"MMR deficiency is common in high-grade endometrioid carcinomas and is associated with an unfavorable outcome","year":2013,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto; Calgary Laboratory Services; University of Calgary","funders":"Health Research Board; Calgary Laboratory Services; Memorial Sloan-Kettering Cancer Center","keywords":"Medicine; PTEN; MSH2; MLH1; Subtyping; Endometrial cancer; Oncology; Univariate analysis; Internal medicine; ARID1A; Cancer; DNA mismatch repair; Multivariate analysis; Mutation; Biology; Apoptosis; Gene; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000347445,0.0002154754,0.000433105,0.0001085938,0.0001067476,0.0000292004,0.0002200759,0.0004322437,0.0002527793],"category_scores_gemma":[0.0002039173,0.0001733407,0.00004417623,0.0002508488,0.0001676543,0.00001125293,0.0001128381,0.000212641,0.00001893785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001656644,"about_ca_system_score_gemma":0.0001599154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001149963,"about_ca_topic_score_gemma":0.002140622,"domain_scores_codex":[0.998345,0.0001882607,0.0003513033,0.000524096,0.0001195815,0.0004717223],"domain_scores_gemma":[0.9991565,0.0001399554,0.0001702861,0.0003251685,0.00008700404,0.0001210908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001003935,0.001025216,0.9361063,0.00003732159,0.0000801619,0.00005325807,0.0004800375,0.0002755615,0.04359415,0.0001057147,0.003493158,0.01464873],"study_design_scores_gemma":[0.009755253,0.01459055,0.940735,0.00002739735,0.0001203595,0.0001282352,0.001228896,0.002842998,0.01831685,0.00259223,0.008506157,0.001156051],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962369,0.0007134569,0.00003742913,0.0007107197,0.0001225952,0.0003598047,0.00002177121,0.00002711388,0.001770233],"genre_scores_gemma":[0.9958627,0.0001664194,0.0008272459,0.002392432,0.00003810805,0.00009459657,0.00007177817,0.00001992918,0.0005268005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0252773,"threshold_uncertainty_score":0.706863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02213431047915189,"score_gpt":0.2848414856488556,"score_spread":0.2627071751697037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}