{"id":"W2004042903","doi":"10.1128/jvi.01014-06","title":"Loss of VHL Confers Hypoxia-Inducible Factor (HIF)-Dependent Resistance to Vesicular Stomatitis Virus: Role of HIF in Antiviral Response","year":2006,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Canada Research Chairs; University of Toronto","funders":"","keywords":"Vesicular stomatitis virus; Biology; Hypoxia-inducible factors; Ubiquitin ligase; Interferon; Downregulation and upregulation; RNA interference; Virus; Carcinogenesis; Cancer research; Virology; Molecular biology; Ubiquitin; RNA; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001040563,0.0001694706,0.0004714113,0.0003411837,0.00003087674,0.000008624034,0.0004109639,0.0002309558,0.00005509993],"category_scores_gemma":[0.0001892926,0.0001613605,0.0001601267,0.0002199606,0.0001807669,0.00001154832,0.00009008097,0.0002405725,0.000005557812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004967605,"about_ca_system_score_gemma":0.0002976343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008381423,"about_ca_topic_score_gemma":0.0009077618,"domain_scores_codex":[0.9976915,0.0006018288,0.0007467223,0.0002495265,0.000366076,0.0003443667],"domain_scores_gemma":[0.9987519,0.00007798134,0.0004545281,0.000379106,0.0002494207,0.00008703505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01841526,0.0002528891,0.006031768,0.00001806872,0.00007913633,0.00008611639,0.00007640202,0.0003627008,0.9738093,0.00003237543,0.000396968,0.0004390237],"study_design_scores_gemma":[0.001538445,0.004651175,0.04881999,0.00003256779,0.00001236324,0.00003157176,0.00006918763,0.000009612226,0.9420233,0.0002930483,0.00238787,0.0001309101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967961,0.002043654,0.0001612109,0.000515457,0.00008159683,0.000168276,0.00007053201,0.000002394945,0.000160763],"genre_scores_gemma":[0.9989446,0.0002007936,0.0004051558,0.0001263834,0.0001120555,0.00000439305,0.0000052595,0.00002523506,0.0001761225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04278822,"threshold_uncertainty_score":0.658009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009452469066675621,"score_gpt":0.2766405231199277,"score_spread":0.2671880540532521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}