{"id":"W2004062881","doi":"10.1158/1535-7163.targ-11-a121","title":"Abstract A121: Direct SH2 domain-targeting inhibitors of Stat3: Potent anticancer agents and mitigators of drug resistance.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"SH2 domain; STAT3; Cancer research; STAT protein; Cancer cell; Cancer; Biology; Chemistry; Signal transduction; Cell biology; Tyrosine phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002082825,0.0002207054,0.0003895918,0.00003395873,0.00005299604,0.000009322374,0.0001798385,0.0001242542,0.0003571777],"category_scores_gemma":[0.00001899065,0.0001744473,0.0001507837,0.0001089836,0.0002684564,0.00004206912,0.00006373238,0.0001481554,6.487337e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005662613,"about_ca_system_score_gemma":0.00004922459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002448142,"about_ca_topic_score_gemma":0.00003142201,"domain_scores_codex":[0.9986454,0.0000459131,0.0004082842,0.0003274688,0.0002899528,0.000282971],"domain_scores_gemma":[0.9991605,0.00007231798,0.0003367156,0.0002578991,0.00008847586,0.00008410152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001992974,0.0002286141,0.03765021,0.0002936972,0.0003215076,0.00001687975,0.0008169661,0.000002658973,0.9501849,0.00009672225,0.00006146621,0.0101271],"study_design_scores_gemma":[0.0003114561,0.00001617632,0.01491017,0.0001867315,0.00008304716,3.806966e-7,0.0002878055,0.000006074845,0.979531,0.0006795873,0.003769877,0.0002177119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876177,0.004477518,0.00003226762,0.000100745,0.0000793758,0.00008462511,0.00008322165,0.00002522926,0.007499279],"genre_scores_gemma":[0.9977932,0.001113863,0.0008079648,0.000140305,0.00003789677,0.00001447613,0.000004145074,0.00002756575,0.0000605635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0293461,"threshold_uncertainty_score":0.7113753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02840876955575181,"score_gpt":0.2526552685595865,"score_spread":0.2242464990038347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}