{"id":"W2004062881","doi":"10.1158/1535-7163.targ-11-a121","title":"Abstract A121: Direct SH2 domain-targeting inhibitors of Stat3: Potent anticancer agents and mitigators of drug resistance.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"SH2 domain; STAT3; Cancer research; STAT protein; Cancer cell; Cancer; Biology; Chemistry; Signal transduction; Cell biology; Tyrosine phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009716107,0.0004745608,0.0002176963,0.000356335,0.0001713874,0.0002400084,0.0003064998,0.0004163698,0.005602166],"category_scores_gemma":[0.00005188489,0.0001062376,0.0003017345,0.0002446953,0.0001201156,0.00021855,0.0002124074,0.0006811199,0.001631417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000176093,"about_ca_system_score_gemma":0.0001961033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002502371,"about_ca_topic_score_gemma":0.0004571041,"domain_scores_codex":[0.9999419,0.00000893002,0.000004292044,0.00001149844,0.00001767249,0.00001573345],"domain_scores_gemma":[0.9999695,0.000003114923,0.000006094758,0.0000023678,0.000004754199,0.0000142248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001664017,0.0008672713,0.0002981856,0.000376974,0.00006127414,0.0003587241,0.00002394208,0.0009475659,0.9251971,0.00214194,0.00780175,0.0602613],"study_design_scores_gemma":[0.001272279,0.007795793,0.003728645,0.00005111743,0.000125903,0.001146256,0.00002678148,0.004546435,0.8963488,0.0006271155,0.08428601,0.00004496948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8442071,0.06186885,0.01911383,0.002352336,0.001780225,0.0008652915,0.005009948,0.00141767,0.0633847],"genre_scores_gemma":[0.9363758,0.01650022,0.005984129,0.0008281615,0.0001705986,0.0002472056,0.002781806,0.00005805882,0.03705409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005602166,"threshold_uncertainty_score":0.01874107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02840876955575181,"score_gpt":0.2526552685595865,"score_spread":0.2242464990038347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}