{"id":"W2004064009","doi":"10.1080/07391102.2009.10507299","title":"The Central Region of BRCA1 Binds Preferentially to Supercoiled DNA","year":2009,"lang":"en","type":"article","venue":"Journal of Biomolecular Structure and Dynamics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"DNA; HMG-box; DNA supercoil; Superhelix; Chromatin; Protein–DNA interaction; Molecular biology; DNA-binding protein; Biology; DNA binding site; Electrophoretic mobility shift assay; DNA repair; Chemistry; Cell biology; DNA replication; Transcription factor; Biochemistry; Promoter; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001065192,0.0003239274,0.0002818819,0.0002469864,0.0001924621,0.0002281118,0.0002334521,0.0002349935,0.002234493],"category_scores_gemma":[0.0002571332,0.0002069457,0.0001847668,0.0001564519,0.0003269403,0.0001761895,0.0002069526,0.0003759922,0.0006719432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002364442,"about_ca_system_score_gemma":0.0001961991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008839534,"about_ca_topic_score_gemma":0.0008179519,"domain_scores_codex":[0.9998693,0.00001202599,0.000004089576,0.00005198812,0.00004163165,0.00002093854],"domain_scores_gemma":[0.9997107,0.00008408377,0.00007807033,0.00002064098,0.00003753902,0.00006888388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003443657,0.000005553806,0.0001894392,0.00002441007,0.000002056838,0.00002352914,0.00001505227,0.0000250518,0.9989529,0.00003396931,0.00002128204,0.0006723516],"study_design_scores_gemma":[0.000004008376,0.00009558273,0.01250938,0.000007648058,0.000005831796,0.000364222,0.00003494719,0.0003808963,0.9844951,0.00006374315,0.002032538,0.000006088179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884504,0.002379046,0.00742291,0.00008889594,0.00001669617,0.00001315514,0.0001716278,0.00019273,0.001264482],"genre_scores_gemma":[0.9925844,0.0007063043,0.004197787,0.00005390738,0.000008751956,0.000009995828,0.0004993588,0.0000327956,0.001906739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002234493,"threshold_uncertainty_score":0.007475138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002825434049132389,"score_gpt":0.2431507365772441,"score_spread":0.2403253025281118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}