{"id":"W2004064009","doi":"10.1080/07391102.2009.10507299","title":"The Central Region of BRCA1 Binds Preferentially to Supercoiled DNA","year":2009,"lang":"en","type":"article","venue":"Journal of Biomolecular Structure and Dynamics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"DNA; HMG-box; DNA supercoil; Superhelix; Chromatin; Protein–DNA interaction; Molecular biology; DNA-binding protein; Biology; DNA binding site; Electrophoretic mobility shift assay; DNA repair; Chemistry; Cell biology; DNA replication; Transcription factor; Biochemistry; Promoter; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007114706,0.0001120254,0.0001413042,0.00005131376,0.00004767486,0.00002730233,0.0001657259,0.00009897505,0.000001299311],"category_scores_gemma":[0.00003856176,0.00007778103,0.0000973261,0.00008421735,0.00003325524,0.000003246455,0.0000326278,0.00008120915,4.93161e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001084951,"about_ca_system_score_gemma":0.00004316957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002197647,"about_ca_topic_score_gemma":0.00002486815,"domain_scores_codex":[0.9993033,0.00002328041,0.0002624028,0.0001080675,0.0001341727,0.0001687141],"domain_scores_gemma":[0.9995056,0.000005416793,0.00009988958,0.0001734454,0.0001116602,0.0001039645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001342834,0.00001384865,0.0003707341,0.000009670944,0.00006549701,0.00001125591,0.00006921034,0.0003916906,0.9758366,0.0003274768,0.0001432311,0.02262651],"study_design_scores_gemma":[0.00131164,0.002323907,0.0489072,0.00006763425,0.0001398042,0.0008220311,0.000170568,0.001131521,0.9388055,0.0009692253,0.004997003,0.00035393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9218962,0.0009349762,0.0765071,0.0003495234,0.0001749638,0.00006607633,0.000008197087,0.000001694854,0.0000612285],"genre_scores_gemma":[0.9982528,0.0003559851,0.001114094,0.0001052235,0.000125957,1.751446e-7,0.00001061783,0.000008626042,0.00002654088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07635655,"threshold_uncertainty_score":0.3171819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002825434049132389,"score_gpt":0.2431507365772441,"score_spread":0.2403253025281118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}