{"id":"W2004085727","doi":"10.1007/s12094-014-1203-9","title":"The intra-tumor heterogeneity of cell signaling factors in breast cancer: p4E-BP1 and peIF4E are diffusely expressed and are real potential targets","year":2014,"lang":"en","type":"review","venue":"Clinical & Translational Oncology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Cancer research; Cancer; Medicine; Genetic heterogeneity; Druggability; Tumor progression; Breast cancer; Tumor heterogeneity; Signal transduction; Biology; Cell biology; Phenotype; Genetics; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000858911,0.000432036,0.001641492,0.00006267694,0.0001212286,0.00002421858,0.0003618448,0.0008941401,0.00001971109],"category_scores_gemma":[0.0001030751,0.0003217036,0.0004495563,0.00009004946,0.0006456202,0.000006714182,0.0001014233,0.0006100466,9.060882e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004714672,"about_ca_system_score_gemma":0.0006045274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004696486,"about_ca_topic_score_gemma":0.0003454129,"domain_scores_codex":[0.9962405,0.0008892181,0.001464089,0.0008167793,0.0002243234,0.0003650985],"domain_scores_gemma":[0.9971914,0.00107238,0.001092593,0.0003105206,0.0001452552,0.0001878201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003706727,0.00265066,0.18094,0.01936615,0.002726978,0.0001542597,0.0002625211,0.0007780597,0.03538306,0.0001560931,0.001601993,0.7522734],"study_design_scores_gemma":[0.005488357,0.001306087,0.05557176,0.003425557,0.001540603,0.0001051062,0.00007031496,0.0001889363,0.001737663,0.0003040192,0.9287423,0.001519331],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2008679,0.7965171,0.0001721172,0.0003193018,0.0005999851,0.0005615858,0.0009191338,0.00001017509,0.0000326791],"genre_scores_gemma":[0.2406582,0.7581333,0.0001584012,0.00009893782,0.0006416229,0.00007104413,0.0001822764,0.00004555366,0.00001072391],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9271403,"threshold_uncertainty_score":0.9999235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04576635503499817,"score_gpt":0.3825266236015997,"score_spread":0.3367602685666016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}