{"id":"W2004107411","doi":"10.1016/j.vaccine.2004.07.014","title":"Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine response","year":2004,"lang":"en","type":"article","venue":"Vaccine","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; Ottawa Hospital; Toronto Western Hospital; University of Ottawa","funders":"","keywords":"Avidity; CpG Oligodeoxynucleotide; Adjuvant; Antigen; Antibody; Immunology; Virology; HBsAg; Affinity maturation; Biology; CpG site; Priming (agriculture); Isotype; Immunogenicity; HBcAg; Molecular biology; Monoclonal antibody; Virus; Hepatitis B virus; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003208215,0.0003277436,0.0003296329,0.0001810614,0.0001181641,0.0002561395,0.0001400538,0.0003401116,0.001841121],"category_scores_gemma":[0.0003516545,0.0001622007,0.0001584695,0.00009074968,0.0001822873,0.0002031058,0.0001935715,0.0009398636,0.000426725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001918708,"about_ca_system_score_gemma":0.0002715711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003796995,"about_ca_topic_score_gemma":0.0005545774,"domain_scores_codex":[0.9998275,0.00005662957,0.00001169996,0.00002614788,0.00002681576,0.00005118222],"domain_scores_gemma":[0.9998459,0.00005752532,0.00001826973,0.0000169375,0.00001985723,0.00004155292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00092437,0.0001905151,0.0001255514,0.00003100203,0.000005673769,0.00001742902,0.0000145076,0.00006293428,0.9960735,0.00006904798,0.00005942733,0.002425984],"study_design_scores_gemma":[0.00009877468,0.002826831,0.001368963,0.000005312859,0.00002300308,0.0001090589,0.00001308609,0.0005901426,0.9937308,0.00003366323,0.001197041,0.000003471455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996709,0.0007409525,0.001295438,0.00007566812,0.00006680263,0.00004930703,0.00004582052,0.00003950273,0.0009776148],"genre_scores_gemma":[0.9959953,0.0003652748,0.00121951,0.00007586198,0.0000365891,0.00004196326,0.0001263522,0.00001642791,0.002122832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001841121,"threshold_uncertainty_score":0.006159186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01852173194176587,"score_gpt":0.3178005161757669,"score_spread":0.2992787842340011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}