{"id":"W2004155058","doi":"10.1016/s0002-9440(10)63103-3","title":"Retrovirally Mediated Overexpression of Versican V3 Reverses Impaired Elastogenesis and Heightened Proliferation Exhibited by Fibroblasts from Costello Syndrome and Hurler Disease Patients","year":2004,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; U.S. Public Health Service; National Institutes of Health","keywords":"Versican; Tropoelastin; Dermatan sulfate; Chemistry; Elastin; Chondroitin sulfate proteoglycan; Cell biology; Proteoglycan; Chondroitin sulfate; Elastic fiber; Pericyte; Glycosaminoglycan; Biochemistry; Pathology; Endothelial stem cell; Extracellular matrix; Biology; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009321195,0.0004288717,0.0002179111,0.0004173333,0.0002240546,0.000324331,0.0001943734,0.0002828068,0.001898991],"category_scores_gemma":[0.0001675602,0.0001593504,0.0002148679,0.0001986034,0.0002560409,0.0001259053,0.0001489166,0.0004350483,0.0004165155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001718943,"about_ca_system_score_gemma":0.0001768638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001041014,"about_ca_topic_score_gemma":0.00169006,"domain_scores_codex":[0.9998943,0.00001414048,0.00001466819,0.00001871255,0.00003315482,0.00002512867],"domain_scores_gemma":[0.9998593,0.00003352799,0.00004548832,0.00001630968,0.000008496379,0.00003686655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007471543,0.00001404747,0.0002992639,0.00001099327,0.000005409964,0.0004436735,0.00001944227,0.00005320356,0.9982731,0.0001003514,0.00003177954,0.0006740708],"study_design_scores_gemma":[0.00007882961,0.0003441524,0.01786295,0.000008731631,0.00005521751,0.008861476,0.0001487243,0.00173734,0.9676017,0.0001131276,0.003173751,0.00001397699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978688,0.0002213834,0.0006980207,0.00003653177,0.00001778583,0.00001269299,0.000219571,0.00004717659,0.0008779845],"genre_scores_gemma":[0.997534,0.0001683052,0.0007261453,0.00001558494,0.00001003475,0.00001192422,0.0002427337,0.0000193189,0.001271927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001898991,"threshold_uncertainty_score":0.006352782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003813358292723264,"score_gpt":0.2137805902630883,"score_spread":0.2099672319703651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}