{"id":"W2004193133","doi":"10.1016/j.fgb.2012.08.006","title":"A defect in iron uptake enhances the susceptibility of Cryptococcus neoformans to azole antifungal drugs","year":2012,"lang":"en","type":"article","venue":"Fungal Genetics and Biology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Ministry of Education, Science and Technology; National Research Foundation of Korea","keywords":"Biology; Mutant; Cryptococcus neoformans; Fluconazole; Antifungal drug; Transcriptome; Azole; Biochemistry; Microbiology; Gene; Gene expression; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001678471,0.000288332,0.000288912,0.0003933383,0.0001681245,0.0003208628,0.00027008,0.0004353485,0.001691645],"category_scores_gemma":[0.0004581026,0.0001721523,0.0002084196,0.0001833286,0.0003663885,0.0001560093,0.0002591422,0.0004680567,0.0002947446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000432183,"about_ca_system_score_gemma":0.0002708872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002266445,"about_ca_topic_score_gemma":0.001746016,"domain_scores_codex":[0.9997616,0.00005365718,0.00002187167,0.00002838758,0.00006304911,0.0000713265],"domain_scores_gemma":[0.9995667,0.0001127628,0.00009782066,0.00005510306,0.00004843481,0.0001191965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002725489,0.00008156436,0.0006070862,0.000009346581,0.000004645556,0.000185967,0.000009878267,0.00004341947,0.9979305,0.00006645938,0.00003614213,0.0007523875],"study_design_scores_gemma":[0.00005564598,0.0005110679,0.02395143,0.00001147897,0.00002657043,0.001824665,0.00008954974,0.002169422,0.9702196,0.0001617209,0.0009674618,0.00001133767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999077,0.0000778055,0.0002331906,0.00006639887,0.000009124792,0.000007665109,0.00005425818,0.00001743875,0.0004569278],"genre_scores_gemma":[0.9988837,0.00004896642,0.0003066668,0.00002528209,0.000003625347,0.000003297197,0.00005269321,0.000008385296,0.0006674117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002266445,"threshold_uncertainty_score":0.005659103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03038083421583669,"score_gpt":0.3179043506234752,"score_spread":0.2875235164076385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}