{"id":"W2004203772","doi":"10.1016/j.yjmcc.2010.08.019","title":"A structural and functional perspective into the mechanism of Ca2+-sensitizers that target the cardiac troponin complex","year":2010,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; British Heart Foundation","keywords":"Troponin I; Levosimendan; Biophysics; Chemistry; Troponin C; Troponin complex; Cardiac muscle; Inotrope; Cardiology; Internal medicine; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006250897,0.0001435203,0.0006131701,0.0000657502,0.0001739757,0.00001175607,0.00005886345,0.0000959009,0.00000832811],"category_scores_gemma":[0.0001009316,0.00007554692,0.0004123875,0.000063818,0.0005963743,0.0000259869,0.00008129316,0.0004849924,2.784332e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000226545,"about_ca_system_score_gemma":0.00006942768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004659424,"about_ca_topic_score_gemma":0.000003036247,"domain_scores_codex":[0.9989882,0.000244724,0.000220245,0.0001431936,0.0002508409,0.0001528007],"domain_scores_gemma":[0.9991441,0.0001175416,0.0001667135,0.0001806622,0.0003157256,0.00007522143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004275235,0.000007086262,0.00355068,0.00002195624,0.001767989,0.0004138271,0.003052212,0.00003115141,0.9700374,0.0197878,0.0004548723,0.0004474957],"study_design_scores_gemma":[0.01001342,0.003337775,0.3215933,0.0001092922,0.008323014,0.04433433,0.1086489,0.0004275236,0.4352964,0.04642288,0.02053568,0.0009574424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848915,0.008935559,0.002372264,0.002296701,0.0006907528,0.0001677257,0.000007487409,0.000003805058,0.0006342316],"genre_scores_gemma":[0.9986768,0.0002620841,0.0003680981,0.0002426266,0.0004136098,0.000002483169,0.000003293549,0.00001091665,0.00002004187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.534741,"threshold_uncertainty_score":0.3080714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218248565097883,"score_gpt":0.2311688311840406,"score_spread":0.2189863455330617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}